Acta Cryst. (2002). E58, o1072-o1074  [ doi:10.1107/S160053680201588X ]

A monoclinic polymorph of venlafaxine hydrochloride

A. Sivalakshmidevi, K. Vyas, S. Mahender Rao and G. Om Reddy

Abstract: Venlafaxine hydrochloride, [()-N,N-dimethyl-2-(1-hydroxycyclohex-1-yl)-2-(4-methoxyphenyl) ethylamine hydrochloride, C₁₇H₂₈ClNO₂] is found to crystallize in both orthorhombic and monoclinic crystal systems. The molecular structures in the two polymorphs differ in the conformations of the substituents at the ethylamine group. In the monoclinic crystal structure, the molecules translated along the a axis are linked by Cl^- ions through O-HCl and N-HCl hydrogen bonds to form infinite one-dimensional chains.

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