Acta Cryst. (2003). E59, o756-o758  [ doi:10.1107/S1600536803008948 ]

(5aR,8aR,9R)-9-(3,4,5-Trimethoxyphenyl)-5a,6,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione

J.-F. Shi and Y.-G. Wang

Abstract: The title compound, C₂₂H₂₀O₈, a product of oxidation of podophyllotoxin, a lignan of the phenyltetralin type, represents a synthon for potential antitumour agents. It has the same configuration of three chiral centres as the starting material, podophyllotoxin, and, as well as the latter, contains a -lactone ring trans-fused to the tricylic system. Non-classical C-HO hydrogen bonds link the molecules in the crystal structure into infinite chains along the a axis.

Online 9 May 2003

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