Acta Cryst. (2003). E59, o1575-o1577  [ doi:10.1107/S160053680302107X ]

3-(5,7-Dimethoxy-2,2-dimethyl-2H-benzo[b]pyran-6-yl)propionic acid: a potential inhibitor against Leishmania

M. Silva, H. B. Napolitano, J. Ellena, W. C. Rocha, P. C. Vieira, G. Oliva and O. H. Thiemann

Abstract: The title acid, C₁₆H₂₀O₅, was extracted from Adiscanthus fusciflorus (Rutaceae) and is shown to inhibit adenine phosphoribosyltransferase (APRT) enzyme activity. This compound crystallizes in the centrosymmetric space group C2/c with one molecule in the asymmetric unit. There is one strong hydrogen bond, with O_DO_A = 2.6238  (12)  Å and O_D-HO_A = 171.1  (17)° involving the COOH group, forming a cyclic dimer about a center of symmetry. The packing of the molecules is additionally stabilized by one C-HO [C_DO_A = 2.9820  (16)  Å and C_D-HO_A = 101.8  (10)°] and two C-H intermolecular hydrogen bonds.

Online 30 September 2003

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