Acta Cryst. (2003). E59, o1506-o1508  [ doi:10.1107/S1600536803019925 ]

Redetermination and comparative structural study of isopimpinellin: a new inhibitor against the Leishmania APRT enzyme

H. B. Napolitano, M. Silva, J. Ellena, W. C. Rocha, P. C. Vieira, O. H. Thiemann and G. Oliva

Abstract: The title compound (alternative name 5,8-dimethoxypsoralen), C₁₃H₁₀O₅, is a natural product extracted from Adiscanthus fusciflorus (Rutaceae). Our biochemical tests show that this compound has inhibitory activity against the enzyme adenine phosphoribosyltransferase (APRT) from Leishmania, a tropical parasite causing endemic disease in poor countries. It crystallizes in the centrosymmetric space group P2₁/c, with one molecule in the asymmetric unit, and has at least two C-HO intermolecular interactions, leading to the formation of centrosymmetric dimers.

Online 18 September 2003

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