Acta Cryst. (2003). E59, o1509-o1511  [ doi:10.1107/S1600536803020324 ]

3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide

L. Dupont, F. Somers, P. D. Tullio and B. Pirotte

Abstract: The crystal structure of the title compound, C₁₀H₁₁N₃O₄S₂, an inactive dithiazine analogue of 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides that are known to be pancreatic B-cell selective K_ATP channel openers, reveals that the exocyclic NH group and the alkyl chain are oriented in the same spatial direction as in the active thiadiazine derivatives. The lack of activity is probably the result of the replacement of the NH group in the 4-position by an S atom. The crystal packing involves one N-HO hydrogen bond.

Online 18 September 2003

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