Acta Cryst. (2003). E59, o1631-o1633  [ doi:10.1107/S1600536803021196 ]

Beclomethasone dipropionate crystallized from HFA-134a and ethanol

J. A. Harris, M. D. Carducci and P. B. Myrdal

Abstract: Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C₂H₂F₄, and 200-proof ethanol. The formula of the crystalline material is C₂₈H₃₇ClO₇·2C₂H₆O·C₂H₂F₄. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.

Online 7 October 2003

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