Acta Cryst. (2003). E59, o1807-o1809  [ doi:10.1107/S1600536803023729 ]

Conformational isomerism in 3-(Z)-isobutylidene-1-acetylpiperazine-2,5-dione

W. A. Loughlin, M. A. McCleary and P. C. Healy

Abstract: The title compound, C₁₀H₁₄N₂O₃, (I), is a key intermediate in the synthesis of the cyclic dehydropeptide albonoursin, which has been found to exhibit useful biological and pharmacological properties. It crystallizes with two molecules in the asymmetric unit with different conformational structures. The methylpropylidene side chain is found to be in the Z configuration about the C=C double bond for both molecules.

Online 23 October 2003

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