Acta Cryst. (2003). E59, o1925-o1926  [ doi:10.1107/S1600536803025467 ]

tert-Butyl (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionate

W. Clegg and L. Horsburgh

Abstract: The title compound, C₂₂H₂₄INO₄, is a chiral reagent developed and used for the synthesis of unnatural amino acids. It forms chains in its crystal structure, via weak N-HO=C hydrogen bonds. The bulky iodo substituent lies gauche to the two substituents on the neighbouring C atom, about a C-C single bond, rather than gauche to one and trans to the other. This does not seem to be a consequence of any significant intermolecular interactions. The absolute configuration has been confirmed by this experiment and is as expected from the synthesis.

Online 8 November 2003

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