Acta Cryst. (2003). E59, o1888-o1890  [ doi:10.1107/S1600536803024425 ]

An ethanol solvate of Beclomethasone dipropionate

P. J. Kuehl, M. D. Carducci and P. B. Myrdal

Abstract: Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C₂₈H₃₇ClO₇·2C₂H₆O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.

Online 8 November 2003

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