Acta Cryst. (2004). E60, o66-o68  [ doi:10.1107/S160053680302806X ]

Polymorphic form II of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

I. Wawrzycka-Gorczyca, A. E. Koziol, M. Glice and J. Cybulski

Abstract: The title compound, C₁₇H₂₀N₄S, generic name olanzapine, is an antipsychotic agent. The molecule consists of three fused rings (benzene, diazepine and thiophene) and an N-methylpiperazine substituent. The boat conformation of the central 1,5-diazepine ring defines the overall shape of the molecule. Two butterfly-like molecules form centrosymmetric dimers stabilized by C-H interactions between their cavities. The dimers are connected by intermolecular N-HN, C-HN and C-HS hydrogen bonds.

Online 12 December 2003

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