Acta Cryst. (2004). E60, o241-o243  [ doi:10.1107/S160053680400100X ]

4-Amino-2,6-dichloro-5-nitropyrimidine

D. McKeveney, R. J. Quinn, C. O. Janssen and P. C. Healy

Abstract: The title compound, C₄H₂Cl₂N₄O₂, is a key intermediate in the synthesis of a purine scaffold, as nucleophilic substitution of the chlorides allows access to a diverse array of potentially biologically active compounds. The molecules exhibit an intramolecular N-HO hydrogen bond between the ortho amino and nitro substituents. Pairs of molecules associate across a crystallographic centre of symmetry through N-HN intermolecular hydrogen bonding between the ortho amino group and the ring N atom.

Online 23 January 2004

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