May 2004 issue
Cover illustration: This compound is a member of a new series of nociceptin ligands, based on the 1,3-dihydroindolin-2-one heterocyclic scaffold. Although a weak agonist, changing only the configuration of the cyclohexyl-isopropyl group from trans to cis produces a strong agonist. See Deschamps, Parrish, Zaveri & Jiang [Acta Cryst. E60, o791-o792].