Acta Cryst. (2004). E60, o1817-o1819  [ doi:10.1107/S1600536804022822 ]

N-(3-Methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide (ZD4054 Form 1)

B. Stensland and R. J. Roberts

Abstract: The title compound, C₁₉H₁₆N₆O₄S, crystallizes from N-methylpyridine in the centrosymmetric space group P2₁/n with four molecules in the unit cell. The molecule has 11 heteroatoms, of which only one is protonated. This potential hydrogen-bond donor, viz. the NH amide group, participates in both intra- and intermolecular hydrogen-bond interactions, thus contributing to the stabilization of the molecular conformation and the linking of molecules as dimers. The hairpin-like folded molecule is arranged with three of its four aromatic rings in two parallel planes intersected by a sulfonamide moiety. In this way, the molecules stack efficiently, facilitated by short-range van der Waals forces. No residual volume for solvent inclusion was found.

Online 25 September 2004

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