Acta Cryst. (2004). E60, o2160-o2162  [ doi:10.1107/S1600536804026790 ]

N-[(2'-Cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: an intermediate in the synthesis of valsartan

H. S. Yathirajan, B. Nagaraj, S. L. Gaonkar, R. S. Narasegowda, P. Nagaraja, B. Prabhuswamy and M. Bolte

Abstract: The title compound {systematic name: methyl 2-[(2'-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride}, C₂₀H₂₃N₂O₂⁺·Cl^-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

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