Acta Cryst. (2005). E61, o174-o175  [ doi:10.1107/S1600536804033471 ]

Phthaloyl amlodipine

H. S. Yathirajan, B. Nagaraj and M. Bolte

Abstract: The title compound [alternatively called 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(2-phthalmidoethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate or ethyl methyl (4RS)-4-(2-chlorophenyl)-2-({[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]oxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate], C₂₈H₂₇ClN₂O₇, is a calcium channel blocker and belongs to the family of anti-anginal and antihypertensive reagents. The dihydropyridine ring adopts an envelope conformation. The molecular conformation is stabilized by an intramolecular N-HO hydrogen bond.

Online 24 December 2004

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