3-[(2R*,3S*)-3-(4-Chloro­phenyl)-3-(2-methoxy­anilino)-2-methyl­propionyl]­spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one

Jian, S.-Z.; Gu, J.-M.; Wang, Y.-G.

doi:10.1107/S1600536805005854

3-[(2R,3S)-3-(4-Chlorophenyl)-3-(2-methoxyanilino)-2-methylpropionyl]spiro[2H-1,3-benzoxazine-2,1′-cyclohexan]-4(3H)-one

S.-Z. Jian, J.-M. Gu and Y.-G. Wang

The title compound, C₃₀H₃₁ClN₂O₄, crystallizes as discrete molecules. Non-classical C—H

O hydrogen bonds link the molecules in the crystal structure into a sheet parallel to ( $\overline 1$ 01).

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Supporting information

	Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536805005854/hg6138sup1.cif Contains datablocks global, 3
	Structure factor file (CIF format) https://doi.org/10.1107/S1600536805005854/hg61383sup2.hkl Contains datablock 3

CCDC reference: 270429

checkCIF report

Key indicators

Single-crystal X-ray study
T = 293 K
Mean (C-C) = 0.003 Å
R factor = 0.038
wR factor = 0.102
Data-to-parameter ratio = 15.6

checkCIF/PLATON results

No syntax errors found



Alert level C
PLAT152_ALERT_1_C Supplied and Calc Volume s.u. Inconsistent .....          ?
PLAT480_ALERT_4_C Long H...A H-Bond Reported H241   ..  O4      ..       2.62 Ang.
PLAT482_ALERT_4_C Small D-H..A Angle Rep for N2     ..  O4      ..      96.00 Deg.

   0 ALERT level A = In general: serious problem
   0 ALERT level B = Potentially serious problem
   3 ALERT level C = Check and explain
   0 ALERT level G = General alerts; check

   1 ALERT type 1 CIF construction/syntax error, inconsistent or missing data
   0 ALERT type 2 Indicator that the structure model may be wrong or deficient
   0 ALERT type 3 Indicator that the structure quality may be low
   2 ALERT type 4 Improvement, methodology, query or suggestion

Computing details top

Data collection: PROCESS-AUTO (Rigaku Corporation,1998); cell refinement: PROCESS-AUTO; data reduction: CrystalStructure 3.6.0 (Rigaku/MSC, 2004); program(s) used to solve structure: SHELXS97 (Sheldrick,1997); program(s) used to refine structure: CRYSTALS (Watkin et al.,1996); molecular graphics: WinGX (Farrugia, 1999); software used to prepare material for publication: CrystalStructure 3.6.0.

(3) top

Crystal data top

C₃₀H₃₁ClN₂O₄	F(000) = 1096.00
M_r = 519.04	D_x = 1.278 Mg m⁻³
Monoclinic, P2₁/n	Mo Kα radiation, λ = 0.7107 Å
Hall symbol: -P 2yn	Cell parameters from 13437 reflections
a = 14.7792 (3) Å	θ = 2.2–27.5°
b = 16.7390 (2) Å	µ = 0.18 mm⁻¹
c = 14.6920 (3) Å	T = 293 K
β = 132.0900 (5)°	Block, colorless
V = 2697.24 (8) Å³	0.33 × 0.30 × 0.17 mm
Z = 4

Data collection top

Rigaku R-AXIS RAPID diffractometer	5221 reflections with F² > 2σ(F²)
Detector resolution: 10.00 pixels mm^-1	R_int = 0.028
ω scans	θ_max = 27.5°
Absorption correction: multi-scan (ABSCOR; Higashi, 1995)	h = −19→19
T_min = 0.925, T_max = 0.970	k = −21→21
25182 measured reflections	l = −19→19
6039 independent reflections

Refinement top

Refinement on F²	w = 1/[0.0009F_o² + σ(F_o²)]/(4F_o²)
R[F² > 2σ(F²)] = 0.038	(Δ/σ)_max < 0.001
wR(F²) = 0.102	Δρ_max = 0.29 e Å⁻³
S = 1.01	Δρ_min = −0.26 e Å⁻³
5221 reflections	Extinction correction: Larson (1970), equation 22
335 parameters	Extinction coefficient: 231 (36)
H-atom parameters constrained

Special details top

Geometry. ENTER SPECIAL DETAILS OF THE MOLECULAR GEOMETRY

Refinement. Refinement using all reflections. The weighted R-factor (wR) and goodness of fit (S) are based on F². R-factor (gt) are based on F. The threshold expression of F² > 2.0 σ(F²) is used only for calculating R-factor (gt).

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
Cl(1)	−0.02323 (4)	0.48001 (3)	−0.25630 (4)	0.0653 (1)
O(1)	0.2652 (1)	0.82569 (6)	0.3288 (1)	0.0467 (3)
O(2)	0.2908 (1)	0.63642 (6)	0.4647 (1)	0.0514 (3)
O(3)	0.0352 (1)	0.78008 (7)	0.4021 (1)	0.0532 (3)
O(4)	0.55329 (9)	0.58872 (7)	0.4960 (1)	0.0520 (3)
N(1)	0.1832 (1)	0.75266 (7)	0.3907 (1)	0.0402 (3)
N(2)	0.3618 (1)	0.65965 (7)	0.2993 (1)	0.0424 (4)
C(1)	0.2453 (1)	0.69213 (8)	0.1902 (1)	0.0363 (4)
C(2)	0.1638 (1)	0.70366 (9)	0.2190 (1)	0.0364 (4)
C(3)	0.0346 (1)	0.7323 (1)	0.1074 (1)	0.0514 (5)
C(4)	0.2147 (1)	0.76554 (9)	0.3185 (1)	0.0363 (4)
C(5)	0.2186 (1)	0.68110 (9)	0.4538 (1)	0.0415 (4)
C(6)	0.1593 (1)	0.66331 (9)	0.5009 (1)	0.0479 (5)
C(7)	0.1882 (2)	0.5940 (1)	0.5688 (2)	0.0644 (6)
C(8)	0.1202 (3)	0.5742 (1)	0.5994 (2)	0.0824 (8)
C(9)	0.0243 (3)	0.6219 (2)	0.5611 (2)	0.0865 (9)
C(10)	−0.0049 (2)	0.6907 (1)	0.4955 (2)	0.0711 (7)
C(11)	0.0644 (2)	0.7120 (1)	0.4670 (2)	0.0520 (5)
C(12)	0.1327 (1)	0.81669 (9)	0.4164 (1)	0.0425 (4)
C(13)	0.2304 (1)	0.8492 (1)	0.5455 (2)	0.0498 (5)
C(14)	0.1808 (2)	0.9153 (1)	0.5743 (2)	0.0687 (7)
C(15)	0.1189 (2)	0.9809 (1)	0.4792 (2)	0.0711 (7)
C(16)	0.0199 (2)	0.9474 (1)	0.3513 (2)	0.0670 (6)
C(17)	0.0716 (2)	0.8835 (1)	0.3225 (2)	0.0569 (5)
C(18)	0.4610 (1)	0.65158 (8)	0.3103 (1)	0.0380 (4)
C(19)	0.4656 (1)	0.6792 (1)	0.2247 (1)	0.0476 (5)
C(20)	0.5712 (2)	0.6703 (1)	0.2440 (2)	0.0601 (6)
C(21)	0.6717 (2)	0.6327 (1)	0.3471 (2)	0.0636 (6)
C(22)	0.6691 (1)	0.6042 (1)	0.4342 (2)	0.0552 (5)
C(23)	0.5661 (1)	0.61303 (9)	0.4167 (1)	0.0422 (4)
C(24)	0.6531 (2)	0.5472 (1)	0.6045 (1)	0.0607 (5)
C(25)	0.1825 (1)	0.63793 (8)	0.0788 (1)	0.0369 (4)
C(26)	0.1666 (1)	0.55728 (9)	0.0859 (1)	0.0403 (4)
C(27)	0.1034 (1)	0.50865 (9)	−0.0162 (1)	0.0428 (4)
C(28)	0.0563 (1)	0.54092 (9)	−0.1265 (1)	0.0452 (4)
C(29)	0.0717 (2)	0.6203 (1)	−0.1361 (1)	0.0581 (5)
C(30)	0.1352 (2)	0.6684 (1)	−0.0331 (1)	0.0516 (5)
H(1)	0.2597	0.7443	0.1717	0.040*
H(2)	0.1573	0.6525	0.2468	0.042*
H(201)	0.3563	0.6444	0.3551	0.051*
H(7)	0.2558	0.5598	0.5948	0.075*
H(8)	0.1404	0.5262	0.6481	0.102*
H(9)	−0.0244	0.6063	0.5813	0.118*
H(10)	−0.0733	0.7241	0.4693	0.094*
H(19)	0.3940	0.7052	0.1497	0.059*
H(20)	0.5736	0.6912	0.1833	0.081*
H(21)	0.7450	0.6259	0.3592	0.081*
H(22)	0.7411	0.5777	0.5082	0.063*
H(26)	0.2007	0.5344	0.1648	0.050*
H(27)	0.0923	0.4518	−0.0100	0.054*
H(30)	0.1469	0.7251	−0.0396	0.058*
H(131)	0.2964	0.8709	0.5537	0.063*
H(132)	0.2610	0.8060	0.6037	0.063*
H(140)	0.1223	0.8921	0.5766	0.091*
H(142)	0.2480	0.9382	0.6537	0.091*
H(151)	0.1792	1.0080	0.4825	0.098*
H(152)	0.0828	1.0187	0.4969	0.098*
H(161)	−0.0145	0.9903	0.2920	0.086*
H(162)	−0.0434	0.9238	0.3461	0.086*
H(171)	0.0056	0.8613	0.2420	0.071*
H(172)	0.1311	0.9080	0.3224	0.071*
H(229)	0.0379	0.6428	−0.2151	0.063*
H(241)	0.6236	0.5159	0.6348	0.065*
H(242)	0.6908	0.5128	0.5860	0.064*
H(243)	0.7119	0.5851	0.6659	0.065*
H(301)	0.0378	0.7874	0.0917	0.057*
H(302)	−0.0177	0.7266	0.1241	0.058*
H(303)	0.0037	0.7008	0.0370	0.058*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
Cl(1)	0.0691 (3)	0.0595 (3)	0.0491 (3)	−0.0123 (2)	0.0321 (2)	−0.0176 (2)
O(1)	0.0498 (6)	0.0419 (6)	0.0515 (7)	−0.0063 (5)	0.0352 (6)	−0.0041 (5)
O(2)	0.0550 (7)	0.0449 (6)	0.0500 (7)	0.0119 (6)	0.0335 (6)	0.0078 (5)
O(3)	0.0481 (7)	0.0498 (7)	0.0697 (8)	−0.0052 (5)	0.0427 (6)	−0.0056 (6)
O(4)	0.0450 (6)	0.0584 (7)	0.0447 (6)	0.0144 (5)	0.0268 (6)	0.0125 (5)
N(1)	0.0499 (7)	0.0355 (7)	0.0433 (7)	0.0052 (6)	0.0345 (7)	0.0027 (6)
N(2)	0.0348 (7)	0.0585 (8)	0.0339 (7)	0.0079 (6)	0.0230 (6)	0.0061 (6)
C(1)	0.0354 (8)	0.0361 (8)	0.0319 (7)	0.0036 (6)	0.0204 (7)	0.0029 (6)
C(2)	0.0339 (7)	0.0367 (8)	0.0350 (8)	0.0011 (6)	0.0215 (7)	0.0009 (6)
C(3)	0.0365 (9)	0.060 (1)	0.0453 (9)	0.0035 (8)	0.0222 (8)	−0.0040 (8)
C(4)	0.0317 (7)	0.0376 (8)	0.0351 (8)	0.0048 (7)	0.0205 (7)	0.0031 (6)
C(5)	0.0447 (9)	0.0376 (8)	0.0359 (8)	−0.0032 (7)	0.0244 (7)	−0.0030 (7)
C(6)	0.055 (1)	0.0458 (9)	0.0415 (9)	−0.0124 (8)	0.0317 (8)	−0.0074 (7)
C(7)	0.082 (1)	0.056 (1)	0.050 (1)	−0.013 (1)	0.042 (1)	0.0010 (9)
C(8)	0.109 (2)	0.076 (1)	0.071 (1)	−0.026 (1)	0.064 (1)	0.003 (1)
C(9)	0.109 (2)	0.095 (2)	0.091 (2)	−0.041 (2)	0.081 (2)	−0.020 (1)
C(10)	0.075 (1)	0.075 (1)	0.086 (1)	−0.027 (1)	0.063 (1)	−0.021 (1)
C(11)	0.057 (1)	0.053 (1)	0.055 (1)	−0.0187 (9)	0.0407 (9)	−0.0149 (8)
C(12)	0.0447 (9)	0.0406 (8)	0.0530 (9)	−0.0003 (7)	0.0371 (8)	−0.0033 (7)
C(13)	0.056 (1)	0.0471 (9)	0.056 (1)	−0.0096 (8)	0.0416 (9)	−0.0093 (8)
C(14)	0.078 (1)	0.069 (1)	0.080 (1)	−0.018 (1)	0.062 (1)	−0.029 (1)
C(15)	0.082 (1)	0.047 (1)	0.115 (2)	−0.003 (1)	0.079 (1)	−0.016 (1)
C(16)	0.071 (1)	0.051 (1)	0.094 (2)	0.013 (1)	0.061 (1)	0.003 (1)
C(17)	0.065 (1)	0.047 (1)	0.066 (1)	0.0145 (9)	0.046 (1)	0.0073 (9)
C(18)	0.0364 (8)	0.0350 (8)	0.0406 (8)	−0.0021 (6)	0.0250 (7)	−0.0066 (6)
C(19)	0.049 (1)	0.0486 (9)	0.050 (1)	−0.0007 (8)	0.0357 (9)	−0.0010 (8)
C(20)	0.067 (1)	0.060 (1)	0.076 (1)	−0.006 (1)	0.057 (1)	−0.003 (1)
C(21)	0.051 (1)	0.064 (1)	0.088 (1)	−0.0005 (9)	0.051 (1)	−0.005 (1)
C(22)	0.0405 (9)	0.051 (1)	0.065 (1)	0.0048 (8)	0.0317 (9)	−0.0005 (9)
C(23)	0.0389 (8)	0.0368 (8)	0.0460 (9)	0.0007 (7)	0.0265 (8)	−0.0038 (7)
C(24)	0.057 (1)	0.054 (1)	0.048 (1)	0.0161 (9)	0.0254 (9)	0.0096 (8)
C(25)	0.0350 (8)	0.0379 (8)	0.0351 (8)	0.0061 (6)	0.0224 (7)	0.0042 (6)
C(26)	0.0447 (9)	0.0414 (8)	0.0398 (9)	0.0064 (7)	0.0303 (8)	0.0058 (7)
C(27)	0.0474 (9)	0.0362 (8)	0.0518 (9)	0.0009 (7)	0.0361 (8)	0.0004 (7)
C(28)	0.0429 (9)	0.0445 (9)	0.0407 (9)	0.0001 (7)	0.0250 (8)	−0.0050 (7)
C(29)	0.073 (1)	0.048 (1)	0.0347 (9)	0.0010 (9)	0.0289 (9)	0.0041 (7)
C(30)	0.067 (1)	0.0377 (9)	0.0400 (9)	0.0009 (8)	0.0319 (8)	0.0039 (7)

Geometric parameters (Å, º) top

Cl(1)—C(28)	1.748 (2)	C(25)—C(30)	1.383 (3)
O(1)—C(4)	1.201 (2)	C(26)—C(27)	1.381 (2)
O(2)—C(5)	1.223 (3)	C(27)—C(28)	1.375 (3)
O(3)—C(11)	1.357 (2)	C(28)—C(29)	1.372 (2)
O(3)—C(12)	1.446 (3)	C(29)—C(30)	1.383 (2)
O(4)—C(23)	1.361 (3)	N(2)—H(201)	0.9124
O(4)—C(24)	1.431 (2)	C(1)—H(1)	0.9800
N(1)—C(4)	1.432 (3)	C(2)—H(2)	0.9800
N(1)—C(5)	1.385 (2)	C(3)—H(301)	0.9600
N(1)—C(12)	1.493 (3)	C(3)—H(302)	0.9600
N(2)—C(1)	1.460 (1)	C(3)—H(303)	0.9600
N(2)—C(18)	1.370 (3)	C(7)—H(7)	0.9800
C(1)—C(2)	1.533 (3)	C(8)—H(8)	0.9800
C(1)—C(25)	1.525 (2)	C(9)—H(9)	0.9800
C(2)—C(3)	1.538 (2)	C(10)—H(10)	0.9800
C(2)—C(4)	1.517 (2)	C(13)—H(131)	0.9700
C(5)—C(6)	1.465 (4)	C(13)—H(132)	0.9700
C(6)—C(7)	1.398 (3)	C(14)—H(140)	0.9700
C(6)—C(11)	1.394 (3)	C(14)—H(142)	0.9700
C(7)—C(8)	1.387 (5)	C(15)—H(151)	0.9700
C(8)—C(9)	1.376 (5)	C(15)—H(152)	0.9700
C(9)—C(10)	1.373 (4)	C(16)—H(161)	0.9700
C(10)—C(11)	1.387 (5)	C(16)—H(162)	0.9700
C(12)—C(13)	1.519 (2)	C(17)—H(171)	0.9700
C(12)—C(17)	1.517 (2)	C(17)—H(172)	0.9700
C(13)—C(14)	1.534 (4)	C(19)—H(19)	0.9800
C(14)—C(15)	1.511 (3)	C(20)—H(20)	0.9800
C(15)—C(16)	1.517 (3)	C(21)—H(21)	0.9800
C(16)—C(17)	1.530 (4)	C(22)—H(22)	0.9800
C(18)—C(19)	1.384 (3)	C(24)—H(241)	0.9600
C(18)—C(23)	1.420 (2)	C(24)—H(242)	0.9600
C(19)—C(20)	1.394 (4)	C(24)—H(243)	0.9600
C(20)—C(21)	1.371 (2)	C(26)—H(26)	0.9800
C(21)—C(22)	1.390 (4)	C(27)—H(27)	0.9800
C(22)—C(23)	1.372 (4)	C(29)—H(229)	0.9800
C(25)—C(26)	1.386 (2)	C(30)—H(30)	0.9800

Cl(1)—C(28)—C(27)	119.7 (1)	H(201)—N(2)—C(18)	126.8402
Cl(1)—C(28)—C(29)	119.3 (1)	H(1)—C(1)—C(2)	108.7459
O(1)—C(4)—N(1)	121.1 (2)	C(1)—C(2)—H(2)	108.5756
O(1)—C(4)—C(2)	124.0 (2)	H(1)—C(1)—C(25)	108.7737
O(2)—C(5)—N(1)	121.4 (2)	H(2)—C(2)—C(3)	108.6035
O(2)—C(5)—C(6)	124.1 (2)	C(2)—C(3)—H(301)	109.3182
C(12)—O(3)—C(11)	115.9 (1)	C(2)—C(3)—H(302)	109.4677
O(3)—C(11)—C(6)	120.8 (2)	C(2)—C(3)—H(303)	109.3612
O(3)—C(11)—C(10)	118.4 (2)	H(2)—C(2)—C(4)	108.5752
O(3)—C(12)—N(1)	106.1 (1)	H(302)—C(3)—H(301)	109.5593
O(3)—C(12)—C(13)	110.7 (2)	H(303)—C(3)—H(301)	109.4654
O(3)—C(12)—C(17)	104.7 (1)	H(303)—C(3)—H(302)	109.6548
O(4)—C(23)—C(18)	113.7 (2)	C(6)—C(7)—H(7)	120.4219
O(4)—C(23)—C(22)	125.5 (1)	H(7)—C(7)—C(8)	120.3472
C(24)—O(4)—C(23)	117.9 (2)	C(7)—C(8)—H(8)	119.9805
N(1)—C(4)—C(2)	114.4 (1)	H(8)—C(8)—C(9)	119.9865
C(5)—N(1)—C(4)	117.5 (2)	C(8)—C(9)—H(9)	119.1249
C(12)—N(1)—C(4)	123.1 (1)	C(9)—C(10)—H(10)	120.6720
C(12)—N(1)—C(5)	118.6 (2)	H(9)—C(9)—C(10)	119.1064
N(1)—C(5)—C(6)	114.5 (2)	H(10)—C(10)—C(11)	120.7175
N(1)—C(12)—C(13)	110.8 (1)	C(12)—C(13)—H(131)	108.8733
N(1)—C(12)—C(17)	113.1 (2)	C(12)—C(13)—H(132)	108.8805
N(2)—C(1)—C(2)	108.1 (1)	C(12)—C(17)—H(171)	108.9680
C(18)—N(2)—C(1)	123.2 (2)	C(12)—C(17)—H(172)	109.0075
N(2)—C(1)—C(25)	112.2 (1)	H(131)—C(13)—C(14)	108.8698
N(2)—C(18)—C(19)	124.1 (1)	H(132)—C(13)—C(14)	108.8614
N(2)—C(18)—C(23)	117.9 (2)	C(13)—C(14)—H(140)	108.8476
C(1)—C(2)—C(3)	112.9 (2)	C(13)—C(14)—H(142)	108.8415
C(1)—C(2)—C(4)	112.2 (1)	H(132)—C(13)—H(131)	109.4539
C(25)—C(1)—C(2)	110.2 (1)	H(140)—C(14)—C(15)	108.8482
C(1)—C(25)—C(26)	120.7 (2)	H(142)—C(14)—C(15)	108.8333
C(1)—C(25)—C(30)	121.0 (1)	C(14)—C(15)—H(151)	109.0728
C(4)—C(2)—C(3)	105.9 (1)	C(14)—C(15)—H(152)	109.0735
C(5)—C(6)—C(7)	120.9 (2)	H(142)—C(14)—H(140)	109.4606
C(5)—C(6)—C(11)	119.3 (2)	C(15)—C(16)—H(162)	109.1495
C(11)—C(6)—C(7)	119.5 (3)	H(151)—C(15)—C(16)	109.0966
C(6)—C(7)—C(8)	119.2 (2)	C(15)—C(16)—H(161)	109.1145
C(6)—C(11)—C(10)	120.8 (2)	H(152)—C(15)—C(16)	109.0376
C(7)—C(8)—C(9)	120.0 (3)	H(152)—C(15)—H(151)	109.4644
C(8)—C(9)—C(10)	121.8 (4)	C(16)—C(17)—H(171)	108.9068
C(9)—C(10)—C(11)	118.6 (3)	C(16)—C(17)—H(172)	109.0096
C(17)—C(12)—C(13)	111.1 (1)	H(162)—C(16)—C(17)	109.1602
C(12)—C(13)—C(14)	111.9 (1)	H(161)—C(16)—C(17)	109.1376
C(12)—C(17)—C(16)	111.5 (2)	H(162)—C(16)—H(161)	109.4594
C(13)—C(14)—C(15)	112.0 (3)	H(172)—C(17)—H(171)	109.4604
C(14)—C(15)—C(16)	111.1 (2)	C(18)—C(19)—H(19)	119.6977
C(15)—C(16)—C(17)	110.8 (2)	H(19)—C(19)—C(20)	119.6593
C(23)—C(18)—C(19)	118.0 (2)	C(19)—C(20)—H(20)	119.6626
C(18)—C(19)—C(20)	120.6 (2)	H(20)—C(20)—C(21)	119.7006
C(18)—C(23)—C(22)	120.8 (2)	C(20)—C(21)—H(21)	120.1031
C(19)—C(20)—C(21)	120.6 (3)	C(21)—C(22)—H(22)	119.8354
C(20)—C(21)—C(22)	119.8 (3)	H(21)—C(21)—C(22)	120.1353
C(21)—C(22)—C(23)	120.2 (2)	H(22)—C(22)—C(23)	119.9811
C(25)—C(26)—C(27)	121.2 (2)	H(242)—C(24)—H(241)	109.4741
C(30)—C(25)—C(26)	118.2 (1)	H(243)—C(24)—H(241)	109.4639
C(25)—C(30)—C(29)	121.1 (2)	H(243)—C(24)—H(242)	109.3262
C(26)—C(27)—C(28)	119.2 (2)	C(25)—C(26)—H(26)	119.4336
C(27)—C(28)—C(29)	121.0 (2)	C(25)—C(30)—H(30)	119.4373
C(28)—C(29)—C(30)	119.3 (2)	C(26)—C(27)—H(27)	120.3668
O(4)—C(24)—H(241)	109.4369	H(26)—C(26)—C(27)	119.3886
O(4)—C(24)—H(242)	109.6548	H(27)—C(27)—C(28)	120.4253
O(4)—C(24)—H(243)	109.4712	C(28)—C(29)—H(229)	120.4107
N(2)—C(1)—H(1)	108.7047	H(229)—C(29)—C(30)	120.3181
H(201)—N(2)—C(1)	109.9252	C(29)—C(30)—H(30)	119.4185

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
N2—H201···O2	0.91	2.37	3.251 (3)	161
N2—H201···O4	0.91	2.36	2.609 (1)	96
C24—H243···O1ⁱ	0.96	2.46	3.287 (2)	144
C24—H241···O4ⁱⁱ	0.96	2.62	3.259 (2)	124

Symmetry codes: (i) x+1/2, −y+3/2, z+1/2; (ii) −x+1, −y+1, −z+1.

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3-[(2R*,3S*)-3-(4-Chloro­phenyl)-3-(2-methoxy­anilino)-2-methyl­propionyl]­spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one

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3-[(2R,3S)-3-(4-Chlorophenyl)-3-(2-methoxyanilino)-2-methylpropionyl]spiro[2H-1,3-benzoxazine-2,1′-cyclohexan]-4(3H)-one