Acta Cryst. (2005). E61, o1350-o1353  [ doi:10.1107/S1600536805010433 ]

Redetermination of para-aminopyridine (fampridine, EL-970) at 150 K

F. P. Anderson, J. F. Gallagher, P. T. M. Kenny and A. J. Lough

Abstract: The structure of fampridine (EL-970) or 4-aminopyridine, C₅H₆N₂, has been redetermined at 150 K. The room-temperature structure has been reported previously [Chao & Schempp (1977). Acta Cryst. B33, 1557-1564]. Pyramidalization at the amine N atom occurs in fampridine, with the N atom 0.133 (11) Å from the plane of the three C/H/H atoms to which it is bonded; the interplanar angle between the pyridyl ring and NH₂ group is 21 (2)°. Aggregation in the solid state occurs by N-HN and N-H(pyridine) interactions with NN and N(centroid) distances of 2.9829 (18) and 3.3954 (15) Å, respectively; a C-H(pyridine) contact completes the intermolecular interactions [C(centroid) = 3.6360 (16) Å].

Online 16 April 2005

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