Acta Cryst. (2005). E61, o1257-o1258  [ doi:10.1107/S1600536805010408 ]

1-(2-Hydroxy-4-isopropoxyphenyl)-2-phenylethanone

S.-P. Zhang, X.-B. Wang and Z.-T. Zhang

Abstract: The title compound, C₁₇H₁₈O₃, is a product of sodium hypochlorite-induced degradation of ipriflavone, a synthetic isoflavone, which, according to some reports, is effective for prevention and treatment of postmenopausal osteoporosis. The dioxyphenyl fragment of the title molecule is almost coplanar with the carbonyl group and approximately orthogonal to the phenyl plane of the 2-phenylethanone group [the dihedral angle is 73.37 (9)°]. The molecule is stabilized by an intramolecular O-HO bond, which closes the almost planar six-membered pseudo-ring. There is a - interaction between the benzene rings of hydroxyisopropoxyphenyl groups of neighbouring molecules (centroid-to-centroid distance 3.673 Å), which links the molecules into infinite chains extending along the c axis of the crystal.

Online 9 April 2005

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