Acta Cryst. (2005). E61, o2164-o2166  [ doi:10.1107/S1600536805018453 ]

2-(Biphenyl-2-yl)-5-(1-methylhydrazino)-1,3,4-thiadiazole: a thiadiazole-hydrazine derivative with anticonvulsant properties

A. Hempel, L. Y. Y. Ma, N. Camerman, D. Mastropaolo and A. Camerman

Abstract: In the title compound, C₁₅H₁₄N₄S, the outer phenyl ring makes an angle of 101.4 (2)° with the plane through the inner benzene ring, and the planes of the thiadiazole ring and the attached benzene ring intersect at an angle of 146.7 (2)°. In addition to weak N-HN hydrogen bonds, creating a two-dimensional network parallel to the bc plane of the crystal structure, there is also one non-standard hydrogen-bond interaction of the type C-HN. Stereochemical comparison with the closely related compound 1-[5-(biphenyl-2-yl)-1,3,4-thiadiazol-2-yl]methanaminium chloride shows that the two compounds utilize the same mechanism for anticonvulsant activity.

Online 17 June 2005

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