Acta Cryst. (2005). E61, m1686-m1688  [ doi:10.1107/S1600536805024001 ]

Losartan potassium 3.5-hydrate, a new crystalline form

X.-R. Hu, Y.-W. Wang and J.-M. Gu

Abstract: The asymmetric unit of the title compound, di--aqua-1:2⁴O:O-triaqua-1³O-dilosartanido-1N;2²N,N'-dipotassium dihydrate, [K₂(C₂₂H₂₂ClN₆O)₂(H₂O)₅]·2H₂O, is composed of two losartan anions, two K⁺ cations and seven water molecules. Some water molecules bridge the potassium ions linking the molecules to form an infinite chain. The two potassium ions have different environments; one is six-coordinated by three water O atoms and three tetrazole N atoms, whereas the other is five-coordinated by five water O atoms. Extensive hydrogen-bonding interactions lead to a three-dimensional structure.

Online 6 August 2005

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