Acta Cryst. (2005). E61, o2798-o2800  [ doi:10.1107/S1600536805023640 ]

Powder study of hydrochlorothiazide form II

A. Florence, A. Johnston, P. Fernandes, K. Shankland, H. N. E. Stevens, S. Osmundsen and A. B. Mullen

Abstract: The crystal structure of hydrochlorothiazide form II, C₇H₈ClN₃O₄S₂, was solved by simulated annealing from laboratory X-ray powder diffraction data collected at room temperature to 1.76 Å resolution. Subsequent Rietveld refinement yielded an R_wp of 0.0376 to 1.49 Å resolution. The molecules crystallize in the space group P2₁/c with one molecule in the asymmetric unit. The structure is stabilized by three N-HN and one N-HO hydrogen-bonded intermolecular interaction.

Online 6 August 2005

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