Acta Cryst. (2005). E61, o3008-o3010  [ doi:10.1107/S1600536805025936 ]

trans-(4-Methylcyclohexylcarbamoyl)phosphonic acid: a representative matrix metalloproteinase (MMP) inhibitor

S. Cohen, Y. Katz, R. Reich and E. Breuer

Abstract: The title compound, C₈H₁₆NO₄P, is the first carbamoylphosphonic acid for which the crystal structure has been solved. The -PO₃H₂ group has three distinct P-O bond distances of 1.483 (1), 1.506 (1) and 1.545 (2) Å. Hydrogen bonds of types P-O-HO=C and N-HO=P [2.416 (2) and 2.954 (2) Å, respectively] connect the molecules to form a chain of condensed ten-membered hydrogen-bonded rings. The second P-O-H group of each phosphonic acid is hydrogen-bonded to an O=P group of the next chain, so serving to link adjacent chains together.

Online 20 August 2005

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