Acta Cryst. (2005). E61, o3576-o3578  [ doi:10.1107/S1600536805031673 ]

Cyproterone and a comparison with its acetate ester

J. de Ruyck, S. Henry de Hassonville, J.-F. Liégeois and J. Wouters

Abstract: The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-3'H-cyclopropa[a]pregna-1,4,6-triene-3,20-dione), C₂₂H₂₇ClO₃, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A.

Online 8 October 2005

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