Acta Cryst. (2005). E61, o4096-o4098  [ doi:10.1107/S1600536805036718 ]

N-[2-(Aminosulfonyl)-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-4-yl]acetamide

Z.-G. Zou, P. Guo and Y.-X. Lu

Abstract: The title compound, C₁₀H₁₄N₂O₅S₃, has been synthesized as a key intermediate in the synthesis of topically active carbonic anhydrase inhibitor MK-0507. N-HO hydrogen bonds are responsible for the formation of centrosymmetric dimers and zigzag molecular chains. The intermolecular non-bonded SO separation in the crystal structure is 3.415 (2) Å, indicating a strong intermolecular interaction between the aminosulfonyl and S-dioxide groups.

Online 16 November 2005

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