Acta Cryst. (2006). E62, o191-o192  [ doi:10.1107/S1600536805041048 ]

(+)-1-[(R)-3,3,3-Trifluoro-2-methoxy-2-phenylpropionyl]-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine methanol solvate

O. M. Peeters, P. L. Polavarapu, P. Zhang, L. Gera and J. Gal

Abstract: The crystal structure and absolute configuration of the title compound, C₃₄H₃₃Cl₂F₃N₄O₅·CH₄O, were determined to examine the validity of van 't Hoff's principle of additivity of optical rotations. The conformation of the dioxolane ring is halfway between an envelope, with the flap at the unsubstituted C atom, and a form twisted about C_methylene-O. The methanol molecule is hydrogen bonded via the OH group to the unsubstituted N atom of the imidazole group.

Online 14 December 2005

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