Acta Cryst. (2006). E62, o592-o594  [ doi:10.1107/S1600536806000705 ]

3,19-(2-Bromobenzylidene)andrographolide

S.-L. Ng, S. R. Sagineedu, I. A. Razak, H.-K. Fun, S. R. Jada and J. Stanslas

Abstract: The title compound, (E)-3-{2-[3-(2-bromophenyl)-6a,10b-dimethyl-8-methyleneperhydronaphtho[2,1-d][1,3]dioxin-7-yl]ethylidene}-4-hydroxy-4,5-dihydrofuran-2(3H)-one, C₂₇H₃₃BrO₅, an andrographolide derivative, was semi-synthesized using andrographolide as a starting material. The structure contains three fused six-membered rings adopting chair conformations and a five-membered ring adopting an envelope conformation. The 2-bromophenyl group is twisted away from the attached ring. O-HO hydrogen bonds in the structure form chains along the b axis which are interlinked via C-HO interactions.

Online 13 January 2006

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