Acta Cryst. (2006). E62, o2669-o2671  [ doi:10.1107/S1600536806020101 ]

Tetragonal polymorph of the 1:1 adduct of sulfathiazole with pyridine

T. N. Drebushchak, M. A. Mikhailenko, E. V. Boldyreva and T. P. Shakhtshneider

Abstract: The title tetragonal polymorph is one of the two sulfathiazole-pyridine adducts, C₉H₉N₃O₂S₂·C₅H₅N, that can be formed either by crystallization from an n-propanol-pyridine solution, or by exposure of solid sulfathiazole to pyridine vapour. The asymmetric unit consists of a hydrogen-bonded sulfathiazole-pyridine pair. Hydrogen bonds of the form N_aniline-HO_sulfonyl form a three-dimensional network. Pyridine molecules linked to sulfathiazole molecules by N_amino-HN_pyridine hydrogen bonds are located in the channels of the sulfathiazole framework which extend along the 4₁ axis. The angle between neighbouring pyridine rings in the channels is 55.2 (3)°. The adduct is stable in pyridine vapour, but decomposes in air under ambient conditions, giving the metastable polymorph I of sulfathiazole [Kruger & Gafner (1972). Acta Cryst. B28, 272-283].

Online 9 June 2006

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