Acta Cryst. (2007). E63, o565-o567  [ doi:10.1107/S1600536807000074 ]

Voriconazole, an antifungal drug

K. Ravikumar, B. Sridhar, K. D. Prasad and A. K. S. Bhujanga Rao

Abstract: Voriconazole [systematic name 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol], C₁₆H₁₄F₃N₅O, (I), is a triazole antifungal medication used to treat serious fungal infections. The dihedral angle between the planes of the fluoropyrimidine and triazole rings is 32.0 (2)° and that between the difluorophenyl and triazole rings is 47.7 (2)°. In addition to the O-HN intramolecular hydrogen bond, C-HO and C-HN interactions contribute to the molecular arrangement in the crystal packing.

Online 10 January 2007

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