Acta Cryst. (2007). E63, o1404-o1406  [ doi:10.1107/S1600536807007829 ]

An orthorhombic polymorph of palonosetron hydrochloride

K. Ravikumar and B. Sridhar

Abstract: A new polymorph of the title compound {systematic name: 2-[(S)-1-azoniabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one chloride}, C₁₉H₂₅ON₂⁺·Cl^-, an anti-emetic and antinausea agent, has been obtained by crystallization from dimethylformamide. In the orthorhombic polymorph reported here, molecules are arranged into polar (001) layers, with adjacent layers in an antiparallel arrangement, whereas in the earlier reported monoclinic form, adjacent layers are arranged in a parallel manner.

Online 23 February 2007

Copyright © International Union of Crystallography
IUCr Webmaster