Acta Cryst. (2007). E63, o1565-o1567  [ doi:10.1107/S160053680700935X ]

4-(4-Difluoromethoxyphenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-dione

H.-X. Lin, X.-H. Wang, B. Xu, T.-H. Yuan and M.-Q. Chen

Abstract: The title compound, C₁₅H₁₄F₂N₂O₃, was obtained in a one-pot three-component reaction from 4-(difluoromethoxy)benzaldehyde, cyclohexane-1,3-dione and urea, with a catalytic amount of p-toluenesulfonic acid. The 4-(difluoromethoxy)phenyl ring is positioned axially, perpendicular to, and bisecting the six-membered heterocyclic ring. The heterocyclic ring adopts a puckered boat conformation, whereas the cyclohexene ring is in a half-chair conformation. The molecules are linked by N-HO, C-HO, N-HF and C-HF intermolecular hydrogen bonds.

Online 2 March 2007

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