(3R*,4R*,5S*)-4-(4-Methylphenyl)-2,3-diphenyl-7-[(R*)-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]decan-10-one oxime

In the title compound, C34H35N3O2, the polysubstituted piperidine ring adopts a chair conformation and the isoxazolidine ring is in an envelope form. The molecules are linked into a chain along the b axis by O—H⋯N, C—H⋯O and C—H⋯N interactions. The chains are cross-linked via weak C—H⋯π interactions.

In the title compound, C 34 H 35 N 3 O 2 , the polysubstituted piperidine ring adopts a chair conformation and the isoxazolidine ring is in an envelope form. The molecules are linked into a chain along the b axis by O-HÁ Á ÁN, C-HÁ Á ÁO and C-HÁ Á ÁN interactions. The chains are cross-linked via weak C-HÁ Á Á interactions.  Table 1 Hydrogen-bond geometry (Å , ).
RSK thanks CSIR, New Delhi, for a Major Research Project.
The molecular structure of the title compound is shown in Fig.1. The isoxazolidine ring has an envelope conformation, as indicated by the puckering parameters Q = 0.492 (6) Å and φ = 34.1 (7)°. The piperidine ring adopts a chair conformation. The  Table 1). The chains are cross-linked via weak C-H···π interactions involving the C31-C36 phenyl ring (centroid Cg1).

Refinement
H atoms were placed at calculated positions and allowed to ride on their carrier atoms with C-H = 0.93-0.98 Å, O-H = 0.82 Å and U iso = 1.2U eq (C) for CH 2 and CH groups, and 1.5U eq for CH 3 and OH groups. In the absence of significant anomalous scattering, the absolute configuration could not be reliably determined and Friedel pairs were merged.
supplementary materials sup-2 Figures Fig. 1. The molecular structure of the title compound, showing 30% probability displacement ellipsoids and the atom-numbering scheme.