1-(4-Methoxyphenyl)-7-phenyl-3-(phenylselenylmethyl)perhydroisoxazolo[2′,3′:1,2]pyrrolo[3,4-b]azetidine-6-spiro-2′-chroman-2,4′-dione

In the title compound, C35H30N2O5Se, the pyrrolidine ring adopts an envelope conformation and the oxazolidine ring is in a twist conformation. The tetrahydropyran ring adopts a half-chair conformation. The methoxyphenyl ring is twisted away from the attached azetidinone ring by 15.7 (1)°. In the crystal structure, intermolecular C—H⋯O interactions link the molecules into a two-dimensional network.

In the title compound, C 35 H 30 N 2 O 5 Se, the pyrrolidine ring adopts an envelope conformation and the oxazolidine ring is in a twist conformation. The tetrahydropyran ring adopts a half-chair conformation. The methoxyphenyl ring is twisted away from the attached azetidinone ring by 15.7 (1) . In the crystal structure, intermolecular C-HÁ Á ÁO interactions link the molecules into a two-dimensional network.

Comment
Chromanones are found to exhibit strong activity in inhibiting in vitro cell growth of human tumour cells (Lampronti et al., 2003). Many chromanone derivatives are versatile intermediates for the synthesis of natural products such as brazillin, hematoxylin, ripariochromene, clausenin, calonlide A and inophyllum B (Koojiman et al.,1984;Ellis et al., 1997;Chenera et al., 1993). Pyrrolidines and pyrroles are common structural motifs in drugs and drug candidates owing to their ability to act as selective glycosidase inhibitors which are used in the treatment of diabetes, cancer, malaria and viral infections including AIDS (Kilonda et al.,1995). The most commonly used β-lactam antibiotics for the therapy of infectious diseases are penicillin and cephalosporin (Brakhage, 1998). In view of the above, the crystal structure determination of the title compound was carried out and the results are presented here.
In the crystal packing, intermolecular C-H···O interactions (Table 1) link the molecules into a two-dimensional network ( Fig. 2).

Experimental
To a solution of the bicyclic nitrone (1 mol) in dry acetonitrile (20 ml) was added 3-arylidene chromanone (1 mol) under a N 2 atmosphere. The reaction was refluxed for 4 h. After the completion of the reaction, the solvent was distilled off under reduced pressure and the crude product was purified by column chromatography. The title compound was crystallized from benzene solution by slow evaporation technique.

Refinement
H atoms were placed in idealized positions and allowed to ride on their parent atoms, with C-H = 0.93-0.98 Å and U iso (H)= 1.2-1.5U eq (C).