Acta Cryst. (2008). E64, o829  [ doi:10.1107/S1600536808009240 ]

Eplerenone ethanol solvate

Q. Yang, W.-D. Ye, J.-Y. Yuan, J.-J. Nie and D.-J. Xu

Abstract: Eplerenone [systematic name: 7-(methoxycarbonyl)-3-oxo-9,11-epoxy-17-pregn-4-ene-21,17-carbolactone], an aldosterone receptor antagonist, crystallizes from ethanol as a monosolvate, C₂₄H₃₀O₆·C₂H₆O. The eplerenone molecule has two five-membered rings, three six-membered rings and one three-membered ring. Both five-membered rings display envelope conformations, while the three six-membered rings assume envelope (cyclohexene), half-chair (cyclohexane sharing one edge with epoxy) and chair (other cyclohexane) conformations. The solvent molecule is disordered equally over two sites. It is linked to the eplerenone molecule by hydrogen bonds.

Online 10 April 2008

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