Ethyl 3-hydr-oxy-13-methyl-4'-phenyl-2'-(3,4,5-trimethoxy-phen-yl)-6,7,8,9,11,12,13,14,15,16-deca-hydro-spiro-[cyclo-penta-[a]phenanthrene-16,3'-pyrrolidine]-5'-carboxyl-ate.

In the title compound, C(39)H(45)NO(7),the pyrrolidine ring is connected to an estrone group, a trimeth-oxy benzene and a phenyl ring. The pyrrolidine ring exhibits a twist conformation and the other five-membered ring an envelope conformation. Mol-ecules are linked by N-H⋯O hydrogen bonds, C-H⋯π inter-actions and C-H⋯O hydrogen bonds.

In the title compound, C 39 H 45 NO 7 ,the pyrrolidine ring is connected to an estrone group, a trimethoxy benzene and a phenyl ring. The pyrrolidine ring exhibits a twist conformation and the other five-membered ring an envelope conformation. Molecules are linked by N-HÁ Á ÁO hydrogen bonds, C-HÁ Á Á interactions and C-HÁ Á ÁO hydrogen bonds.
Derivatives of pyrrolidine are found to have anticonvulsant properties (Obniska et al.,2002). Optically active pyrrolidines have been used as intermediates in controlled asymmetric synthesis (Suzuki et al.,1994).  et al., 1987).
In the crystal packing, atoms O2 and N1 are involved in intermolecular N-H···O interactions and atom O3 is involved in intermolecular C -H···O interactions. The molecules pack into distinct layers facilitated by C -H···π interactions.

S2. Experimental
1.0 mole of (Z)-16-arylidene estrone (0.78 g) and 1.0 mol of ethyl {[(1E)-(3,4,5-trimethoxyphenyl) methylene] amino} acetate (1.0 g) was stirred in 20 ml of acetonitrile contain AgOAc (0.01 g) and triethylamine (2 ml). The reaction was allowed to stir overnight and the reaction was monitored by TLC. After the completion of reaction, the crude white solid was filtered and then purified by preparative HPLC using water and acetonitrile as eluent. The final pure compound was recrystallized using 2:8 ratio of acetone: hexane.

S3. Refinement
In the absence of anomalous scatterers Friedel pairs have been merged. H atoms were placed in idealized positions and allowed to ride on their parent atoms, with C-H = 0.93 or 0.96 Å and U iso (H)= 1.2-1.5U eq (C). supporting information sup-2 . E64, o2219-o2220

Figure 1
The molecular structure of (I) with 30% probability displacement ellipsoids.

Figure 2
The packing of the molecules viewed down c axis. Hydrogen bonds are indicated by dashed lines and C-H···π interactions are also shown.  where P = (F o 2 + 2F c 2 )/3 (Δ/σ) max < 0.001 Δρ max = 0.48 e Å −3 Δρ min = −0.24 e Å −3 Extinction correction: SHELXL97 (Sheldrick, 2008), Fc * =kFc[1+0.001xFc 2 λ 3 /sin(2θ)] -1/4 Extinction coefficient: 0.0112 (9) Special details Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. Refinement. Refinement of F 2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The threshold expression of F 2 > σ(F 2 ) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å 2 )