Acta Cryst. (2008). E64, o2303  [ doi:10.1107/S160053680803568X ]

6-Acetamido-5-hydroxycholestan-3-yl acetate

R. M. A. Pinto, M. Ramos Silva, A. Matos Beja, J. A. R. Salvador and J. A. Paixão

Abstract: The title steroid, C₃₁H₅₃NO₄, was prepared from the corresponding 5,6-epoxycholestane. The conformation of the six-membered rings is close to a chair form, while the five-membered ring adopts a twist conformation. The hydroxyl and acetamide groups are in axial positions. The nucleophilic species bound to the steroid nucleus at position 6 by the -face, whereas the hydroxyl group at position 5 has -orientation. All rings are trans-fused. The crystal packing shows that the molecules related by twofold symmetry exist as O-HO hydrogen-bonded dimers.

Online 8 November 2008

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