Acta Cryst. (2009). E65, o144-o145 [ doi:10.1107/S1600536808041901 ]
Online 17 December 2008
No syntax errors found
Alert level C Value of measurement temperature given = 90.000 Value of melting point given = 0.000 PLAT230_ALERT_2_C Hirshfeld Test Diff for O37 -- N35 .. 5.56 su PLAT230_ALERT_2_C Hirshfeld Test Diff for O40 -- N38 .. 5.43 su
0 ALERT level A = In general: serious problem 0 ALERT level B = Potentially serious problem 2 ALERT level C = Check and explain 0 ALERT level G = General alerts; check 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data 2 ALERT type 2 Indicator that the structure model may be wrong or deficient 0 ALERT type 3 Indicator that the structure quality may be low 0 ALERT type 4 Improvement, methodology, query or suggestion 0 ALERT type 5 Informative message, check
checkCIF publication errors
Alert level A PUBL024_ALERT_1_A The number of authors is greater than 5. Please specify the role of each of the co-authors for your paper.
|Author Response: Five authors are involved in this publication. This response is not present in the Notes for Authors nor does the IUCr CheckCif give this response.|
All of the authors have contributed significantly to the current manuscript. I wrote the original NIH proposal in 1998. Brendan Twamley ably performed the crystallography and structure solution. Monika originally synthesized the compound, and further details were clarified by Trideep Rajale. Rich Bridges and Sary Patel are our pharmacology collaborators, who performed Xc- binding studies, which while being essentially a negative control, is the impetus and inspiration for the work, and this paper will be quite important in the follow on manuscripts, wherein we've discovered an analog in this series with activity comparable to the endogenous substrate. The advance in the study could not have taken place without an SAR study, and the coordinates of this compound were of critical significance in developing our common pharmacophore model. I don't see this as "courtesy" co-authorship, all the authors were actively engaged in the design, performance and execution of this work, and have been involved in the writing of the manuscript.
1 ALERT level A = Data missing that is essential or data in wrong format 0 ALERT level G = General alerts. Data that may be required is missing
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