Acta Cryst. (2009). E65, o79  [ doi:10.1107/S1600536808041068 ]

1,2,3,4-Tetrahydro-1,4-methanonaphthalene-2,3-diol

J. Xu, H. Xu, J. Quan, F. Sha and C. Yao

Abstract: The title compound, C₁₁H₁₂O₂, is an intermediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intramolecular O-HO hydrogen bond that generates an S(5) ring motif. Intermolecular O-HO hydrogen bonds form centrosymmetric dimers and also link these dimers into chains along the a axis.

Online 10 December 2008

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