Acta Cryst. (2009). E65, o432-o433  [ doi:10.1107/S1600536809003365 ]

2-({3-[(2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-2,3,4,5-tetrahydrofuran-2-yl]-5-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl}methyl)isoindoline-1,3-dione

M. D. Bartholomä, W. Ouellette and J. Zubieta

Abstract: The title compound, C₁₉H₁₉N₃O₇, is a thymidine derivative and serves as an intermediate in the synthesis of a ^99mTc radiolabeled nucleoside analog. Intermolecular O-HO hydrogen bonding is observed between the hydroxy functionalities of the ribose unit themselves as well as between a hydroxy group and an O atom of the phthalimide group of an adjacent molecule. The molecules are stacked on top of each other in the direction of the a axis. The crystal packing is further stabilized by weak intra- and intermolecular C-HO hydrogen bonds. The absolute configuration of the compound is known from the synthesis.

Online 31 January 2009

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