Acta Cryst. (2009). E65, o970-o971  [ doi:10.1107/S160053680901160X ]

4-(3-Methylanilino)-N-[N-(1-methylethyl)carbamoyl]pyridinium-3-sulfonamidate (torasemide) methanol 0.25-solvate 0.25-hydrate

G. Bartolucci, B. Bruni, S. A. Coran and M. Di Vaira

Abstract: The title compound, C₁₆H₂₀N₄O₃S·0.25CH₄O·0.25H₂O, is a hydrate/methanol solvate of torasemide, a diuretic drug used in the treatment of hypertension. The asymmetric unit contains two torasemide molecules and half-occupied methanol and water molecules. It is isomorphous with the previously reported nonsolvated T-II form of torasemide. The water molecules contribute to the stability of the structure by participating in an extensive system of O-HO hydrogen bonds; N-HN and N-HO hydrogen bonds are also present. Both asymmetric molecules of torasemide form inversion dimers in the crystal.

Online 8 April 2009

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