Acta Cryst. (2009). E65, o1286  [ doi:10.1107/S1600536809017085 ]

Darifenacin hydrobromide

S. Selvanayagam, B. Sridhar and K. Ravikumar

Abstract: In the title compound {systematic name: (S)-3-[(aminocarbonyl)diphenylmethyl]-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidinium bromide}, C₂₈H₃₁N₂O₂⁺·Br^-, the pyrrolidine rings adopts an envelope conformation. The two phenyl rings make a dihedral angle of 72.5 (1)°. The four coplanar atoms of the pyrrolidine ring makes dihedral angles of 33.1 (2) and 82.8 (2)° with the two phenyl rings. The molecular conformation is influenced by a C-HO interaction. In the crystal packing, there are two N-HBr hydrogen bonds running in opposite directions. They appear to form C(10) and C(9) chain motifs in the unit cell. In addition, the molecular packing is further stabilized by C-HBr and C-HO hydrogen bonds. The C atom bonded to the benzofuran ring system is disordered in a 0.66:0.34 ratio.

Online 14 May 2009

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