Acta Cryst. (2009). E65, o1461-o1462  [ doi:10.1107/S160053680902025X ]

(S)-Methyl 2-[(3R,4R)-2-benzyl-3-(2-furyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamido]-3-(1H-indol-3-yl)propanoate

Z. Baktir, M. Akkurt, M. I. Kandinska, M. G. Bogdanov and O. Büyükgüngör

Abstract: The title compound, C₃₃H₂₉N₃O₅, was synthesized by the reaction of racemic trans-2-benzyl-3-(2-furyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid, L-tryptophan methyl ester and diisopropylcarbodiimide in dry dichloromethane. The furan ring is disordered over two positions in a 0.859 (14):0.141 (14) ratio. In the 1,2,3,4-tetrahydroisoquinoline ring system, the heterocyclic ring is not planar, with puckering parameters Q_T = 0.448 (2) Å, = 64.9 (3) and = 268.3 (3)°. The crystal is extended into a three-dimensional supramolecular architecture through intermolecular N-HO hydrogen bonds and C-H interactions. The absolute structure was assigned by reference to the chiral starting material.

Online 6 June 2009

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