Acta Cryst. (2009). E65, o2220  [ doi:10.1107/S1600536809028293 ]

(8S,9R,10S,11S,13S,14S,16S,17R)-4,4-Dichloro-16-methyl-3,20-dioxo-17,21-bis(propanoyloxy)-5,8-epoxypregna-1,9-diene

K. A. Ketuly, A. H. A. Hadi and S. W. Ng

Abstract: The title compound, C₂₈H₃₄Cl₂O₇, is a derivative of the glucocorticoid steroid beclomethasone dipropionate. It features an expoxide linkage [angle at oxygen = 96.6 (2)°]. The dichlorocyclohexenone ring adopts an envelope conformation, with the C atom bearing the two Cl substituents representing the flap. The dichloromethyl C atom deviates by 0.471 (4) Å from the plane defined by the other five atoms, whose maximum r.m.s. deviation is 0.04 Å.

Online 22 July 2009

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