Acta Cryst. (2009). E65, o2126-o2127  [ doi:10.1107/S1600536809031031 ]

Theophylline-gentisic acid (1/1)

S. Aitipamula, P. S. Chow and R. B. H. Tan

Abstract: In the title 1:1 cocrystal, C₇H₈N₄O₂·C₇H₆O₄, the anti-asthmatic drug theophylline (systematic name: 1,3-dimethyl-7H-purine-2,6-dione) and a non-steroidal anti-inflammatory drug, gentisic acid (systematic name: 2,5-dihydroxybenzoic acid) crystallize together, forming two-dimensional hydrogen-bonded sheets involving N-HO and O-HN hydrogen bonds. The overall crystal packing features - stacking interactions [centroid-centroid distance = 3.348 (1) Å]. The cocrystal described herein belongs to the class of pharmaceutical cocrystals involving two active pharmaceutical ingredients which has been relatively unexplored to date.

Online 8 August 2009

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