Acta Cryst. (2009). E65, o2556 [ doi:10.1107/S1600536809038501 ]
In the crystal of the title compound, C10H14N2O, double supramolecular layers of PhCH2CH2CH2NHC(O)NH2 are formed parallel to the bc plane by intermolecular N-H
O hydrogen bonding, with R22(8) and R21(6) motifs in the b- and c-axis directions, respectively. The mean plane of the Car-C-C group makes a dihedral angle of 84.8 (2)° with the benzene ring.
A toluene suspension of Woollins reagent (0.54 g, 1.0 mmol) and Ph(CH2)3NHCN (0.29 g, 2.0 mmol), which were prepared from cyanogen bromide with primary or secondary amine in dry methanol in the presence of excess of anhydrous CH3COONa at room temperature in almost quantitative yield (Renodon-Cornière et al. 2002), was refluxed for 4 h under nitrogen during which time the mixtures became a clear reddish brown solution. After cooling and addition of water (1 cm3) the reflux was continued for another 1 h. The solvent was removed in vacuum, and the residue was purified by column chromatography (silica gel, 9:1 dichloromethane/ethyl acetate as eluant) to afford the title compound in the yield of 95%. The single crystals of the title compound for the X-ray crystallographic analysis were obtained by recrystallization from dichloromethane/hexane as colorless blocks.
All H atoms except H2 (which was freely refined) were included in calculated positions (C—H distances are 0.98 Å methyl H atoms, 0.99 Å for methylene H atoms and 0.95 Å for aryl H atoms, N—H 0.88 Å) and were refined as riding atoms with Uiso(H) = 1.2 Ueq (parent atom, amino, methylene and aryl H atoms) or Uiso(H) = 1.5 Ueq (parent atom, methyl H atoms).
Data collection: CrystalClear (Rigaku, 2004); cell refinement: CrystalClear (Rigaku, 2004); data reduction: CrystalClear (Rigaku, 2004); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: PLATON (Spek, 2009); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).
![[Figure 1]](./bt5070fig1thm.gif)
| Fig. 1. The molecular structure of the title compound with displacement ellipsoids drawn at the 50% probability level. |
![[Figure 2]](./bt5070fig2thm.gif)
| Fig. 2. View along the b direction of the crystal packing of the title compound with hydrogen bonding shown as dashed lines. |
| C10H14N2O | F(000) = 384 |
| Mr = 178.23 | Dx = 1.169 Mg m−3 |
| Monoclinic, P21/c | Mo Kα radiation, λ = 0.71073 Å |
| a = 17.002 (4) Å | Cell parameters from 2697 reflections |
| b = 6.4953 (15) Å | θ = 2.4–28.1° |
| c = 9.171 (2) Å | µ = 0.08 mm−1 |
| β = 91.401 (8)° | T = 93 K |
| V = 1012.5 (4) Å3 | Platelet, colorless |
| Z = 4 | 0.25 × 0.04 × 0.03 mm |
| Rigaku Mercury CCD diffractometer | 2126 independent reflections |
| Radiation source: rotating anode | 1360 reflections with I > 2σ(I) |
| confocal | Rint = 0.038 |
| Detector resolution: 0.83 pixels mm-1 | θmax = 28.5°, θmin = 3.4° |
| ω scans | h = −16→20 |
| Absorption correction: multi-scan (CrystalClear; Rigaku, 2004) | k = −8→7 |
| Tmin = 0.981, Tmax = 0.998 | l = −9→11 |
| 6696 measured reflections |
| Refinement on F2 | Secondary atom site location: difference Fourier map |
| Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
| R[F2 > 2σ(F2)] = 0.056 | H atoms treated by a mixture of independent and constrained refinement |
| wR(F2) = 0.144 | w = 1/[σ2(Fo2) + (0.0607P)2] where P = (Fo2 + 2Fc2)/3 |
| S = 1.03 | (Δ/σ)max < 0.001 |
| 2126 reflections | Δρmax = 0.23 e Å−3 |
| 122 parameters | Δρmin = −0.20 e Å−3 |
| 0 restraints | Extinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
| Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.030 (5) |
| C10H14N2O | V = 1012.5 (4) Å3 |
| Mr = 178.23 | Z = 4 |
| Monoclinic, P21/c | Mo Kα radiation |
| a = 17.002 (4) Å | µ = 0.08 mm−1 |
| b = 6.4953 (15) Å | T = 93 K |
| c = 9.171 (2) Å | 0.25 × 0.04 × 0.03 mm |
| β = 91.401 (8)° |
| Rigaku Mercury CCD diffractometer | 2126 independent reflections |
| Absorption correction: multi-scan (CrystalClear; Rigaku, 2004) | 1360 reflections with I > 2σ(I) |
| Tmin = 0.981, Tmax = 0.998 | Rint = 0.038 |
| 6696 measured reflections | θmax = 28.5° |
| R[F2 > 2σ(F2)] = 0.056 | H atoms treated by a mixture of independent and constrained refinement |
| wR(F2) = 0.144 | Δρmax = 0.23 e Å−3 |
| S = 1.03 | Δρmin = −0.20 e Å−3 |
| 2126 reflections | Absolute structure: ? |
| 122 parameters | Flack parameter: ? |
| 0 restraints | Rogers parameter: ? |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
| x | y | z | Uiso*/Ueq | ||
| O1 | 0.56839 (7) | 1.2854 (2) | 0.55596 (11) | 0.0367 (4) | |
| N2 | 0.61033 (9) | 1.1114 (2) | 0.35832 (16) | 0.0321 (4) | |
| C5 | 0.81085 (11) | 0.5672 (3) | 0.32854 (16) | 0.0325 (5) | |
| N1 | 0.54532 (10) | 1.4186 (3) | 0.33030 (14) | 0.0401 (5) | |
| H1A | 0.5219 | 1.5274 | 0.3665 | 0.048* | |
| H1B | 0.5499 | 1.4060 | 0.2353 | 0.048* | |
| C2 | 0.64786 (11) | 0.9469 (3) | 0.44128 (17) | 0.0342 (5) | |
| H2A | 0.6075 | 0.8490 | 0.4749 | 0.041* | |
| H2B | 0.6756 | 1.0048 | 0.5282 | 0.041* | |
| C10 | 0.79059 (12) | 0.3888 (3) | 0.25485 (18) | 0.0396 (5) | |
| H10 | 0.7413 | 0.3258 | 0.2721 | 0.047* | |
| C6 | 0.88327 (12) | 0.6552 (3) | 0.3003 (2) | 0.0451 (6) | |
| H6 | 0.8987 | 0.7777 | 0.3497 | 0.054* | |
| C3 | 0.70581 (11) | 0.8358 (3) | 0.34725 (18) | 0.0338 (5) | |
| H3A | 0.7425 | 0.9378 | 0.3063 | 0.041* | |
| H3B | 0.6768 | 0.7703 | 0.2646 | 0.041* | |
| C4 | 0.75349 (11) | 0.6713 (3) | 0.42853 (18) | 0.0354 (5) | |
| H4A | 0.7828 | 0.7353 | 0.5114 | 0.042* | |
| H4B | 0.7174 | 0.5671 | 0.4684 | 0.042* | |
| C9 | 0.84088 (13) | 0.3000 (3) | 0.1561 (2) | 0.0457 (6) | |
| H9 | 0.8259 | 0.1765 | 0.1074 | 0.055* | |
| C8 | 0.91183 (13) | 0.3890 (4) | 0.1284 (2) | 0.0475 (6) | |
| H8 | 0.9459 | 0.3288 | 0.0598 | 0.057* | |
| C7 | 0.93348 (13) | 0.5670 (4) | 0.2009 (2) | 0.0533 (6) | |
| H7 | 0.9828 | 0.6294 | 0.1828 | 0.064* | |
| C1 | 0.57407 (10) | 1.2717 (3) | 0.42002 (17) | 0.0305 (5) | |
| H2 | 0.6095 (11) | 1.110 (3) | 0.264 (2) | 0.037* |
| U11 | U22 | U33 | U12 | U13 | U23 | |
| O1 | 0.0480 (9) | 0.0409 (8) | 0.0211 (7) | 0.0078 (6) | 0.0029 (5) | −0.0016 (5) |
| N2 | 0.0408 (10) | 0.0356 (9) | 0.0199 (8) | 0.0082 (7) | 0.0011 (6) | −0.0016 (6) |
| C5 | 0.0355 (11) | 0.0340 (11) | 0.0280 (9) | 0.0034 (8) | 0.0013 (7) | 0.0026 (7) |
| N1 | 0.0575 (12) | 0.0397 (10) | 0.0232 (8) | 0.0145 (8) | 0.0041 (7) | −0.0004 (6) |
| C2 | 0.0405 (12) | 0.0357 (11) | 0.0264 (9) | 0.0050 (8) | 0.0023 (7) | 0.0009 (7) |
| C10 | 0.0426 (13) | 0.0348 (11) | 0.0415 (11) | −0.0006 (9) | 0.0055 (8) | −0.0006 (8) |
| C6 | 0.0402 (13) | 0.0472 (13) | 0.0480 (12) | −0.0050 (10) | 0.0030 (9) | −0.0113 (9) |
| C3 | 0.0385 (12) | 0.0351 (11) | 0.0281 (10) | 0.0043 (8) | 0.0043 (7) | −0.0005 (7) |
| C4 | 0.0397 (12) | 0.0363 (11) | 0.0303 (10) | 0.0037 (8) | 0.0008 (8) | 0.0013 (7) |
| C9 | 0.0541 (14) | 0.0392 (12) | 0.0440 (12) | 0.0029 (10) | 0.0029 (9) | −0.0079 (9) |
| C8 | 0.0447 (14) | 0.0572 (15) | 0.0408 (12) | 0.0130 (11) | 0.0071 (9) | −0.0058 (10) |
| C7 | 0.0388 (13) | 0.0659 (16) | 0.0557 (13) | −0.0033 (11) | 0.0092 (10) | −0.0079 (11) |
| C1 | 0.0327 (11) | 0.0361 (11) | 0.0228 (10) | 0.0010 (8) | 0.0022 (7) | 0.0001 (7) |
| O1—C1 | 1.2559 (18) | C10—H10 | 0.9500 |
| N2—C1 | 1.342 (2) | C6—C7 | 1.387 (3) |
| N2—C2 | 1.450 (2) | C6—H6 | 0.9500 |
| N2—H2 | 0.863 (18) | C3—C4 | 1.525 (2) |
| C5—C10 | 1.380 (3) | C3—H3A | 0.9900 |
| C5—C6 | 1.388 (3) | C3—H3B | 0.9900 |
| C5—C4 | 1.514 (3) | C4—H4A | 0.9900 |
| N1—C1 | 1.344 (2) | C4—H4B | 0.9900 |
| N1—H1A | 0.8800 | C9—C8 | 1.367 (3) |
| N1—H1B | 0.8800 | C9—H9 | 0.9500 |
| C2—C3 | 1.509 (2) | C8—C7 | 1.379 (3) |
| C2—H2A | 0.9900 | C8—H8 | 0.9500 |
| C2—H2B | 0.9900 | C7—H7 | 0.9500 |
| C10—C9 | 1.386 (3) | ||
| C1—N2—C2 | 123.43 (14) | C4—C3—H3A | 108.8 |
| C1—N2—H2 | 115.5 (12) | C2—C3—H3B | 108.8 |
| C2—N2—H2 | 121.1 (12) | C4—C3—H3B | 108.8 |
| C10—C5—C6 | 117.78 (17) | H3A—C3—H3B | 107.7 |
| C10—C5—C4 | 120.97 (17) | C5—C4—C3 | 111.07 (14) |
| C6—C5—C4 | 121.11 (17) | C5—C4—H4A | 109.4 |
| C1—N1—H1A | 120.0 | C3—C4—H4A | 109.4 |
| C1—N1—H1B | 120.0 | C5—C4—H4B | 109.4 |
| H1A—N1—H1B | 120.0 | C3—C4—H4B | 109.4 |
| N2—C2—C3 | 109.73 (13) | H4A—C4—H4B | 108.0 |
| N2—C2—H2A | 109.7 | C8—C9—C10 | 120.42 (19) |
| C3—C2—H2A | 109.7 | C8—C9—H9 | 119.8 |
| N2—C2—H2B | 109.7 | C10—C9—H9 | 119.8 |
| C3—C2—H2B | 109.7 | C9—C8—C7 | 119.43 (18) |
| H2A—C2—H2B | 108.2 | C9—C8—H8 | 120.3 |
| C5—C10—C9 | 121.23 (19) | C7—C8—H8 | 120.3 |
| C5—C10—H10 | 119.4 | C8—C7—C6 | 120.1 (2) |
| C9—C10—H10 | 119.4 | C8—C7—H7 | 120.0 |
| C7—C6—C5 | 121.1 (2) | C6—C7—H7 | 120.0 |
| C7—C6—H6 | 119.5 | O1—C1—N2 | 121.38 (15) |
| C5—C6—H6 | 119.5 | O1—C1—N1 | 121.44 (16) |
| C2—C3—C4 | 113.74 (14) | N2—C1—N1 | 117.17 (14) |
| C2—C3—H3A | 108.8 | ||
| C1—N2—C2—C3 | −160.22 (17) | C2—C3—C4—C5 | −179.52 (16) |
| C6—C5—C10—C9 | 0.2 (3) | C5—C10—C9—C8 | −0.6 (3) |
| C4—C5—C10—C9 | 175.84 (17) | C10—C9—C8—C7 | 0.8 (3) |
| C10—C5—C6—C7 | 0.2 (3) | C9—C8—C7—C6 | −0.4 (3) |
| C4—C5—C6—C7 | −175.50 (18) | C5—C6—C7—C8 | 0.0 (3) |
| N2—C2—C3—C4 | 175.12 (15) | C2—N2—C1—O1 | −2.2 (3) |
| C10—C5—C4—C3 | −92.9 (2) | C2—N2—C1—N1 | 176.63 (16) |
| C6—C5—C4—C3 | 82.7 (2) |
| D—H···A | D—H | H···A | D···A | D—H···A |
| N1—H1A···O1i | 0.88 | 2.10 | 2.936 (2) | 159 |
| N1—H1B···O1ii | 0.88 | 2.09 | 2.8788 (19) | 148 |
| N2—H2···O1ii | 0.863 (18) | 2.127 (19) | 2.9240 (19) | 153.2 (17) |
| Symmetry codes: (i) −x+1, −y+3, −z+1; (ii) x, −y+5/2, z−1/2. |
| D—H···A | D—H | H···A | D···A | D—H···A |
| N1—H1A···O1i | 0.88 | 2.10 | 2.936 (2) | 159 |
| N1—H1B···O1ii | 0.88 | 2.09 | 2.8788 (19) | 148 |
| N2—H2···O1ii | 0.863 (18) | 2.127 (19) | 2.9240 (19) | 153.2 (17) |
| Symmetry codes: (i) −x+1, −y+3, −z+1; (ii) x, −y+5/2, z−1/2. |
The authors are grateful to the University of St Andrews and the Engineering and Physical Science Research Council (EPRSC, UK) for financial support.
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2,4-Bis(phenyl)-1,3-diselenadiphosphetane-2,4-diselenide [PhP(Se)(µ-Se)]2, which is known as Woollins reagent, WR, has received increasing attention due to its relatively unpleasant chemical properties and since it can be prepared readily and safely handled (Gray et al. 2005). Now it is becoming a very useful selenium source or reagent in synthetic chemistry (Hua et al. 2009; Hua & Woollins, 2009). We report here the synthesis and X-ray structure of C6H4(CH2)3NHCONH2. The title compound was prepared by the reaction of Woollins' reagent with 3-phenylpropan-1-amine.
Double supramolecular layers of the title compound (Fig. 2), PhCH2CH2CH2NHC(O)NH2, are formed parallel to the bc plane by intermolecular N—H···O hydrogen bonding (see Table 1), with R22(8) and R21(6) motifs in approximately b and c directions respectively (Bernstein et al., 1995). The mean plane of the C3—C5 group makes dihedral angle of 84.8 (2)° with the benzene ring.