(IUCr) Crystallography Journals Online

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Acta Cryst. (2009). E65, o2353 [ doi:10.1107/S1600536809034667 ]

Methyl 5,6-dimethoxy-1H-indole-2-carboxylate

T. B. Monroe, Y. Moazami, D. S. Jones and C. A. Ogle

Abstract: The title compound, C₁₂H₁₃NO₄, was prepared as a precursor to an indole derivative with possible antimitotic properties. The molecule is very nearly planar; the maximum deviation of any non-H atom from the mean plane of the indole ring is 0.120 (3) Å for each of two methoxy C atoms. The pairs of molecules related by the inversion centre at (0,0, $1\\over2$ ) are connected by two symmetry-equivalent N-HO hydrogen bonds, while the pairs of molecules related by the inversion centre at (0,0,0) exhibit a [pi] -stacking interaction of the indole rings, with an interplanar separation of 3.39 (3) Å.

Online 5 September 2009