Acta Cryst. (2009). E65, o2603  [ doi:10.1107/S1600536809039002 ]

2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid pyridine solvate

X. Zhu, Y. Wang and T. Lu

Abstract: In the title compound, C₁₆H₁₆N₂O₃S·C₅H₅N, the benzene and thiazole rings of the Febuxostat [2-(3-cyano-4-isobutyloxy)phenyl-4-methyl-5-thiazolecarboxylic acid] molecule are almost coplanar [dihedral angle = 2.4 (1)°]. The carboxyl group is coplanar with the thiazole ring [O-C-C-C and O-C-C-S torsion angles of -0.7 (4) and 0.6 (3)°, respectively]. The pyridine molecule of crystallization is linked to the Febuxostat molecule through an O-HN hydrogen bond. A weak - stacking interaction is observed between the benzene ring of the Febuxostat molecule and pyridine molecule, with a centroid-centroid distance of 3.7530 (18) Å.

Online 3 October 2009

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