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Acta Cryst. (2010). E66, o98    [ doi:10.1107/S1600536809052428 ]

Bis(propan-2-yl) [(2S,3S)-2-hydroxy-3-nitrobutan-2-yl]phosphonate

T. Mandal, S. Samanta, G. A. Broker, C.-G. Zhao and E. R. T. Tiekink

Abstract top

In the title compound, C10H22NO6P, a staggered conformation is found when the molecule is viewed down the central P-C bond, with the oxo and hydroxy groups gauche to each other. The crystal structure features supramolecular chains of helical topology propagating along the b axis, mediated by O-H...O hydrogen bonds.

Comment top

The title compound, (I), was investigated as a part of previous studies on the enantioselective nitroaldol reaction of α-ketophosphonates and nitromethane for the synthesis of optically active α-hydroxy-β-nitrophosphonates (Mandal et al., 2007). The crystal structure analysis of (I), Fig. 1, shows a staggered conformation when the molecule is viewed down the P–C7 axis in which the oxo and hydroxy groups are gauche to each other. The presence of O–H···O hydrogen bonding formed between the hydroxy-O4—H and O═P atoms leads to the formation of supramolecular chains along the b axis, Fig. 2 and Table 1.

Related literature top

For background to the enantioselective nitroaldol reaction of α-ketophosphonates and nitromethane and for the synthesis, see: Mandal et al. (2007).

Experimental top

The title compound was prepared as described in the literature (Mandal et al., 2007).

Refinement top

The C-bound H atoms were geometrically placed (C—H = 0.98–1.00 Å) and refined as riding with Uiso(H) = 1.2–1.5Ueq(C). The methyl H-atoms were rotated to fit the electron density. The O–H H atom was located from a difference map and refined with O–H = 0.840±0.001 Å, and with Uiso(H) = 1.5Ueq(O).

Computing details top

Data collection: CrystalClear (Rigaku/MSC, 2005); cell refinement: CrystalClear (Rigaku/MSC, 2005); data reduction: CrystalClear (Rigaku/MSC, 2005); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: DIAMOND (Brandenburg, 2006); software used to prepare material for publication: publCIF (Westrip, 2009).

Figures top
[Figure 1] Fig. 1. Molecular structure of (I), showing displacement ellipsoids at the 35% probability level.
[Figure 2] Fig. 2. Supramolecular chain along the b axis in (I) mediated by O–H···O (orange dashed lines) hydrogen bonding. Colour scheme: P, olive; O, red; N, blue; C, grey; and H, green.
Bis(propan-2-yl) [(2S,3S)-2-hydroxy-3-nitrobutan-2-yl]phosphonate top
Crystal data top
C10H22NO6PF(000) = 608
Mr = 283.26Dx = 1.244 Mg m−3
Orthorhombic, P212121Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2abCell parameters from 2308 reflections
a = 7.8620 (16) Åθ = 4.0–30.1°
b = 11.369 (2) ŵ = 0.20 mm−1
c = 16.920 (3) ÅT = 173 K
V = 1512.4 (5) Å3Block, pale-yellow
Z = 40.32 × 0.10 × 0.05 mm
Data collection top
Rigaku AFC12K/SATURN724
diffractometer		3072 independent reflections
Radiation source: fine-focus sealed tube3020 reflections with I > 2σ(I)
graphiteRint = 0.089
ω scansθmax = 26.5°, θmin = 4.0°
Absorption correction: multi-scan
(ABSCOR; Higashi, 1995)		h = −9→8
Tmin = 0.884, Tmax = 1k = −13→14
13441 measured reflectionsl = −21→20
Refinement top
Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.040H-atom parameters constrained
wR(F2) = 0.105 w = 1/[σ2(Fo2) + (0.0497P)2 + 0.2822P]
where P = (Fo2 + 2Fc2)/3
S = 1.07(Δ/σ)max = 0.001
3072 reflectionsΔρmax = 0.19 e Å−3
166 parametersΔρmin = −0.25 e Å−3
1 restraintAbsolute structure: Flack (1983), 1272 Friedel pairs
Primary atom site location: structure-invariant direct methodsFlack parameter: 0.05 (11)
Crystal data top
C10H22NO6PV = 1512.4 (5) Å3
Mr = 283.26Z = 4
Orthorhombic, P212121Mo Kα radiation
a = 7.8620 (16) ŵ = 0.20 mm−1
b = 11.369 (2) ÅT = 173 K
c = 16.920 (3) Å0.32 × 0.10 × 0.05 mm
Data collection top
Rigaku AFC12K/SATURN724
diffractometer		3020 reflections with I > 2σ(I)
Absorption correction: multi-scan
(ABSCOR; Higashi, 1995)		Rint = 0.089
Tmin = 0.884, Tmax = 1θmax = 26.5°
13441 measured reflectionsStandard reflections: 0
3072 independent reflections
Refinement top
R[F2 > 2σ(F2)] = 0.040H-atom parameters constrained
wR(F2) = 0.105Δρmax = 0.19 e Å−3
S = 1.07Δρmin = −0.25 e Å−3
3072 reflectionsAbsolute structure: Flack (1983), 1272 Friedel pairs
166 parametersFlack parameter: 0.05 (11)
1 restraint
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
P10.63065 (6)0.29509 (4)0.74005 (3)0.03236 (14)
O10.51586 (18)0.19464 (11)0.75316 (9)0.0416 (3)
O20.80539 (18)0.26553 (13)0.70112 (9)0.0415 (3)
O30.67933 (17)0.36408 (13)0.81677 (8)0.0383 (3)
O40.41385 (17)0.46364 (12)0.71762 (9)0.0400 (3)
H4O0.44480.53370.72410.060*
O50.3878 (4)0.49342 (19)0.51776 (13)0.0848 (7)
O60.1751 (3)0.4227 (2)0.58457 (14)0.0861 (7)
N10.3262 (3)0.4256 (2)0.56573 (14)0.0608 (6)
C10.9313 (3)0.18894 (18)0.74033 (13)0.0438 (5)
H10.87360.14120.78210.053*
C20.9985 (4)0.1089 (3)0.67718 (17)0.0706 (8)
H2A0.90510.06170.65560.106*
H2B1.08490.05670.69980.106*
H2C1.04950.15600.63480.106*
C31.0653 (3)0.2668 (2)0.7782 (2)0.0656 (8)
H3A1.01210.31620.81870.098*
H3B1.11730.31680.73770.098*
H3C1.15300.21750.80260.098*
C40.5800 (3)0.3614 (2)0.89018 (13)0.0551 (6)
H40.46590.32540.88030.066*
C50.5601 (6)0.4848 (3)0.91703 (18)0.0879 (11)
H5A0.49700.52950.87710.132*
H5B0.67260.52020.92460.132*
H5C0.49760.48620.96710.132*
C60.6764 (7)0.2898 (3)0.94900 (18)0.1056 (15)
H6A0.68740.20890.92960.158*
H6B0.61520.28960.99950.158*
H6C0.78970.32380.95650.158*
C70.5409 (2)0.40550 (16)0.67209 (11)0.0336 (4)
C80.4436 (3)0.33911 (18)0.60636 (12)0.0419 (5)
H80.37220.27700.63180.050*
C90.5556 (4)0.2804 (2)0.54440 (13)0.0558 (6)
H9A0.48380.24060.50530.084*
H9B0.62990.22270.57000.084*
H9C0.62510.34010.51790.084*
C100.6767 (3)0.49079 (18)0.64308 (14)0.0430 (5)
H10A0.73120.52870.68850.065*
H10B0.62390.55090.60950.065*
H10C0.76230.44770.61250.065*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
P10.0303 (2)0.0284 (2)0.0384 (2)0.00159 (18)0.00078 (17)0.00062 (19)
O10.0432 (7)0.0284 (6)0.0532 (8)−0.0023 (5)−0.0002 (6)0.0044 (7)
O20.0357 (7)0.0454 (8)0.0435 (7)0.0140 (6)0.0051 (6)0.0031 (6)
O30.0365 (7)0.0426 (7)0.0359 (7)−0.0048 (6)0.0024 (5)−0.0017 (6)
O40.0342 (7)0.0316 (7)0.0541 (8)0.0031 (6)0.0021 (6)−0.0080 (6)
O50.1205 (19)0.0631 (12)0.0708 (13)0.0063 (14)−0.0288 (14)0.0171 (10)
O60.0593 (13)0.1078 (17)0.0912 (16)0.0212 (13)−0.0342 (12)−0.0093 (14)
N10.0736 (16)0.0513 (12)0.0576 (12)0.0103 (11)−0.0261 (11)−0.0073 (11)
C10.0408 (10)0.0399 (11)0.0507 (11)0.0124 (8)−0.0022 (9)0.0007 (10)
C20.0768 (19)0.0698 (17)0.0650 (16)0.0410 (16)−0.0121 (14)−0.0150 (14)
C30.0423 (12)0.0584 (15)0.096 (2)0.0113 (11)−0.0130 (13)−0.0103 (14)
C40.0576 (14)0.0725 (16)0.0351 (10)−0.0157 (12)0.0104 (9)−0.0010 (10)
C50.128 (3)0.085 (2)0.0507 (15)0.038 (2)0.0216 (17)−0.0070 (15)
C60.189 (5)0.081 (2)0.0471 (15)0.029 (3)0.004 (2)0.0180 (16)
C70.0344 (9)0.0283 (8)0.0383 (9)0.0022 (7)−0.0010 (8)−0.0021 (8)
C80.0498 (12)0.0332 (9)0.0428 (10)0.0031 (9)−0.0088 (9)−0.0032 (9)
C90.0772 (17)0.0502 (13)0.0399 (11)0.0049 (13)0.0000 (11)−0.0097 (10)
C100.0451 (11)0.0334 (10)0.0506 (12)−0.0024 (9)0.0042 (9)0.0032 (9)
Geometric parameters (Å, °) top
P1—O11.4723 (14)C4—C51.483 (4)
P1—O21.5602 (14)C4—C61.492 (4)
P1—O31.5643 (15)C4—H41.0000
P1—C71.8428 (19)C5—H5A0.9800
O2—C11.476 (2)C5—H5B0.9800
O3—C41.467 (2)C5—H5C0.9800
O4—C71.424 (2)C6—H6A0.9800
O4—H4O0.8400C6—H6B0.9800
O5—N11.219 (3)C6—H6C0.9800
O6—N11.230 (4)C7—C101.524 (3)
N1—C81.514 (3)C7—C81.546 (3)
C1—C21.500 (3)C8—C91.523 (3)
C1—C31.517 (3)C8—H81.0000
C1—H11.0000C9—H9A0.9800
C2—H2A0.9800C9—H9B0.9800
C2—H2B0.9800C9—H9C0.9800
C2—H2C0.9800C10—H10A0.9800
C3—H3A0.9800C10—H10B0.9800
C3—H3B0.9800C10—H10C0.9800
C3—H3C0.9800
O1—P1—O2115.86 (9)C4—C5—H5A109.5
O1—P1—O3114.44 (9)C4—C5—H5B109.5
O2—P1—O3104.06 (8)H5A—C5—H5B109.5
O1—P1—C7112.80 (9)C4—C5—H5C109.5
O2—P1—C7102.75 (8)H5A—C5—H5C109.5
O3—P1—C7105.67 (8)H5B—C5—H5C109.5
C1—O2—P1121.86 (13)C4—C6—H6A109.5
C4—O3—P1124.17 (14)C4—C6—H6B109.5
C7—O4—H4O108.0H6A—C6—H6B109.5
O5—N1—O6124.9 (3)C4—C6—H6C109.5
O5—N1—C8118.1 (2)H6A—C6—H6C109.5
O6—N1—C8117.0 (2)H6B—C6—H6C109.5
O2—C1—C2105.91 (18)O4—C7—C10111.74 (15)
O2—C1—C3108.14 (17)O4—C7—C8105.60 (16)
C2—C1—C3114.2 (2)C10—C7—C8115.18 (18)
O2—C1—H1109.5O4—C7—P1104.31 (12)
C2—C1—H1109.5C10—C7—P1111.47 (14)
C3—C1—H1109.5C8—C7—P1107.80 (13)
C1—C2—H2A109.5N1—C8—C9108.94 (19)
C1—C2—H2B109.5N1—C8—C7108.11 (16)
H2A—C2—H2B109.5C9—C8—C7115.0 (2)
C1—C2—H2C109.5N1—C8—H8108.2
H2A—C2—H2C109.5C9—C8—H8108.2
H2B—C2—H2C109.5C7—C8—H8108.2
C1—C3—H3A109.5C8—C9—H9A109.5
C1—C3—H3B109.5C8—C9—H9B109.5
H3A—C3—H3B109.5H9A—C9—H9B109.5
C1—C3—H3C109.5C8—C9—H9C109.5
H3A—C3—H3C109.5H9A—C9—H9C109.5
H3B—C3—H3C109.5H9B—C9—H9C109.5
O3—C4—C5107.2 (2)C7—C10—H10A109.5
O3—C4—C6107.8 (2)C7—C10—H10B109.5
C5—C4—C6111.4 (3)H10A—C10—H10B109.5
O3—C4—H4110.1C7—C10—H10C109.5
C5—C4—H4110.1H10A—C10—H10C109.5
C6—C4—H4110.1H10B—C10—H10C109.5
O1—P1—O2—C1−63.20 (17)O3—P1—C7—C1068.93 (15)
O3—P1—O2—C163.34 (17)O1—P1—C7—C8−37.99 (17)
C7—P1—O2—C1173.35 (15)O2—P1—C7—C887.48 (15)
O1—P1—O3—C4−21.1 (2)O3—P1—C7—C8−163.73 (13)
O2—P1—O3—C4−148.58 (17)O5—N1—C8—C9−47.5 (3)
C7—P1—O3—C4103.58 (19)O6—N1—C8—C9133.2 (2)
P1—O2—C1—C2136.98 (19)O5—N1—C8—C778.1 (3)
P1—O2—C1—C3−100.2 (2)O6—N1—C8—C7−101.1 (3)
P1—O3—C4—C5−132.8 (2)O4—C7—C8—N151.7 (2)
P1—O3—C4—C6107.1 (3)C10—C7—C8—N1−72.1 (2)
O1—P1—C7—O473.94 (14)P1—C7—C8—N1162.77 (16)
O2—P1—C7—O4−160.59 (12)O4—C7—C8—C9173.70 (17)
O3—P1—C7—O4−51.80 (13)C10—C7—C8—C949.9 (2)
O1—P1—C7—C10−165.33 (14)P1—C7—C8—C9−75.2 (2)
O2—P1—C7—C10−39.85 (16)
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
O4—H4o···O1i0.841.902.7289 (19)172
Symmetry codes: (i) −x+1, y+1/2, −z+3/2.
Table 1
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
O4—H4o···O1i0.841.902.7289 (19)172
Symmetry codes: (i) −x+1, y+1/2, −z+3/2.
Acknowledgements top

CGZ thanks the Welch Foundation (grant No. AX-1593) and the NIH-MBRS program (S06 GM08194) for support.

references
References top

Brandenburg, K. (2006). DIAMOND. Crystal Impact GbR, Bonn, Germany.

Flack, H. D. (1983). Acta Cryst. A39, 876–881.

Higashi, T. (1995). ABSCOR. Rigaku Corporation, Tokyo, Japan.

Mandal, T., Samanta, S. & Zhao, C.-G. (2007). Org. Lett. 9, 943–945.

Rigaku/MSC (2005). CrystalClear. Rigaku/MSC Inc., The Woodlands, Texas, USA.

Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122.

Westrip, S. P. (2009). publCIF. In preparation.