Received 3 March 2010
In the title compound, C25H18N2O4, the tetrahydropyridine ring adopts a distorted envelope conformation with the spiro C atom at the flap position [deviation = 0.470 (2) Å]. The dihydro-oxazole ring is planar (r.m.s. deviation = 0.013 Å) and it makes dihedral angles of 73.43 (8) and 4.24 (8)° with the two attached phenyl rings. The dihedral angle between oxetane and oxazole planes is 67.44 (9)°. In the crystal structure, C-HO hydrogen bonds link neighbouring molecules into zigzag chains along the b axis and these chains are linked via C-H interactions.
For general background to and applications of isoquinolinedione derivatives, see: Hall et al. (1994); Malamas & Hohman (1994); Nan et al. (2004). For ring conformations, see: Cremer & Pople (1975). For related structures, see: Fun et al. (2010); Wang et al. (2000). For bond-length data, see: Allen et al. (1987). For the stability of the temperature controller used for the data collection, see: Cosier & Glazer (1986).
Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009).
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: CI5051 ).
HKF and JHG thank Universiti Sains Malaysia (USM) for the Research University Golden Goose grant (No. 1001/PFIZIK/811012). Financial support from the Ministry of Science and Technology of China of the Austria-China Cooperation project (grant No. 2007DFA41590) is acknowledged. JHG also thanks USM for the award of a USM fellowship.
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