8-(2-Chlorophenyl)-1-(4-chlorophenyl)-4-[(E)-(2-chlorophenyl)methylidene]-6-methyl-4,5,6,7,7a,8-hexahydro-1,2,4-oxadiazolo[5,4-d]pyrido[3,4-c][1,5]benzothiazepine

In the title compound, C33H26Cl3N3OS, the oxadiazole, piperidine and benzothiapezine rings adopt envelope, chair and twist-boat conformations, respectively. In the crystal, the molecular aggregation is characterized by chains of centrosymmetrically related pairs connected through Cl⋯Cl interactions [3.533 (2) Å], extending parallel to (202).

In the title compound, C 33 H 26 Cl 3 N 3 OS, the oxadiazole, piperidine and benzothiapezine rings adopt envelope, chair and twist-boat conformations, respectively. In the crystal, the molecular aggregation is characterized by chains of centrosymmetrically related pairs connected through ClÁ Á ÁCl interactions [3.533 (2) Å ], extending parallel to (202).
Experimental Crystal data C 33 H 26

Comment
The title compound, C 33 H 26 N 3 OCl 3 S, belongs to an important class of heterocycles which exhibit antihypertensive properties. The compound consists of a benzothiazepine, a oxadiazole and a methyl piperidine ring. Benziothiazepines are regarded as a class of calcium channel blockers (Budriesi et al., 2007), oxadiazol derivatives are established as micobicides (Sahin et al., 2002) and piperidines are established as key components of anti-Parkinson's drugs. Accurate description of the molecular geometry of such molecules are indispensable to proceed with the pharmacological investigations which may prove useful in the design of drugs with a wide range of activities. Also, the role of non-conventional hydrogen bonds viz.
Figures Fig. 1. The molecular structure of (I), with atom labels and 50% probability displacement ellipsoids for non-H atoms. H atoms have been omitted for clarity.

Special details
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F 2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The threshold expression of F 2 > σ(F 2 ) is used only for calculating Rfactors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.