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ISSN: 2056-9890

4-(4-Meth­­oxy­phen­yl)-2-methyl­but-3-yn-2-ol

aInstitut für Organische Chemie, TU Bergakademie Freiberg, Leipziger Str. 29, D-09596 Freiberg/Sachsen, Germany
*Correspondence e-mail: edwin.weber@chemie.tu-freiberg.de

(Received 22 June 2010; accepted 23 June 2010; online 30 June 2010)

The mol­ecular structure of the title compound, C12H14O2, features a nearly coplanar arrangement including the aromatic ring, the C≡C—C group and the ether O atom. The maximum deviation from the least-squares plane of these ten atoms is 0.0787 (8) Å for the ether O atom. In the crystal, mol­ecules are connected via O—H⋯O hydrogen bonds (involving the hy­droxy O atom both as hydrogen-bond donor and acceptor) and weaker (ar­yl)C—H⋯π(ar­yl) contacts, leading to the formation of strands running parallel to the b axis. Further stabilization results from weaker (meth­yl)C—H⋯π(acetyl­ene) inter­actions between different strands.

Related literature

For general background to the Sonogashira–Hagihara coupling reaction and for applications of terminal aryl­alkynes, see: Chinchilla & Nájera (2007[Chinchilla, R. & Nájera, C. (2007). Chem. Rev. 107, 874-922.]); Sonogashira (1998[Sonogashira, K. (1998). Metal-catalyzed Cross-coupling Reactions, edited by F. Diederich & P. J. Stang, pp. 216-220. Weinheim: Wiley-VCH.]). For an alternative synthesis of the title compound, also including analytical data, see: Mayr & Halberstadt-Kausch (1982[Mayr, H. & Halberstadt-Kausch, I. K. (1982). Chem. Ber. 115, 3479-3515.]). For C–H⋯π hydrogen bonding, see: Nishio et al. (2009[Nishio, M., Umezawa, Y., Honda, K., Tsuboyama, S. & Suezawa, H. (2009). CrystEngComm, 11, 1757-1788.]).

[Scheme 1]

Experimental

Crystal data
  • C12H14O2

  • Mr = 190.23

  • Orthorhombic, P b c a

  • a = 16.0390 (13) Å

  • b = 5.8399 (5) Å

  • c = 22.5298 (19) Å

  • V = 2110.3 (3) Å3

  • Z = 8

  • Mo Kα radiation

  • μ = 0.08 mm−1

  • T = 153 K

  • 0.60 × 0.28 × 0.24 mm

Data collection
  • Bruker Kappa APEXII CCD diffractometer

  • Absorption correction: multi-scan (SADABS; Bruker, 2007[Bruker (2007). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wisconsin, USA.]) Tmin = 0.928, Tmax = 0.981

  • 39990 measured reflections

  • 1956 independent reflections

  • 1662 reflections with I > 2σ(I)

  • Rint = 0.025

Refinement
  • R[F2 > 2σ(F2)] = 0.037

  • wR(F2) = 0.114

  • S = 1.10

  • 1956 reflections

  • 131 parameters

  • H-atom parameters constrained

  • Δρmax = 0.23 e Å−3

  • Δρmin = −0.21 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

Cg1 and π2 are the centroid of the C1–C6 aromatic ring and the midpoint of the C8≡C9 bond, respectively.

D—H⋯A D—H H⋯A DA D—H⋯A
O2—H1⋯O2i 0.84 2.31 3.1463 (7) 178
C5—H5⋯Cg1i 0.95 2.96 3.7452 (12) 141
C11—H11Bπ2ii 0.98 2.80 3.7443 (14) 161
Symmetry codes: (i) [-x+{\script{1\over 2}}, y+{\script{1\over 2}}, z]; (ii) -x+1, -y, -z+1.

Data collection: APEX2 (Bruker, 2007[Bruker (2007). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wisconsin, USA.]); cell refinement: SAINT (Bruker, 2007[Bruker (2007). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wisconsin, USA.]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]) and ORTEP-3 (Farrugia, 1997[Farrugia, L. J. (1997). J. Appl. Cryst. 30, 565.]); software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009[Spek, A. L. (2009). Acta Cryst. D65, 148-155.]).

Supporting information


Comment top

Terminal arylalkynes are of general interest in organic chemistry as they can be used for subsequent coupling reactions leading to diarylalkynes which are important building blocks in materials science (Chinchilla & Nájera, 2007). Compounds of this type can be prepared in a two-step reaction where an aryl halide is reacted with 2-methylbut-3-yn-2-ol (a monoprotected acetylene) in a Sonogashira-Hagihara reaction followed by deprotection of the resulting acetylenic compound using a base-catalysed retro-Favorsky elimination of acetone (Sonogashira, 1998).

Following this strategy, the title compound, which is important as an intermediate for the preparation of the terminal arylalkyne 4-ethinylanisole, was prepared via a Sonogashira-Hagihara coupling reaction starting from 4-bromoanisole and 2-methylbut-3-yn-2-ol. Crystallization from cyclohexane yielded colourless needles suitable for an X-ray crystal structure analysis on which is reported herein.

The title compound, C12H14O2, crystallizes in the orthorhombic space group Pbca. The asymmetric unit consists of one molecule which is illustrated in Fig. 1. The atoms C1–C6, C8–C10 and O1 are arranged nearly coplanar. Only the ether O atom O1 deviates slightly from the least-squares plane involving the mentioned atoms. The deviation between this least-squares plane and O1 is 0.0787 (8) Å, the deviation of all other atoms ranges from 0.0023 (11) to 0.0390 (10) Å. The methoxy methyl group is only marginally distorted towards this least-squares plane (torsion angles of -2.84 (18)° and 176.38 (11)° for C5–C4–O1–C7 and C3–C4–O1–C7, respectively). The angle between the least-squares plane (C1–C6, C8–C10, O1) and the least-squares plane of the atoms C9, C10 and O2 is 40.60 (11)°.

In the crystal, the hydroxy O atom O2 is involved in an O2–H1···O2 hydrogen bond leading to the formation of one-dimensional strands located parallel to the b axis (Fig. 2). Within these strands further stabilization is reached via a weak C–H···π interaction (Nishio et al., 2009) of the type (aryl)C–H···π(aryl) between C5–H5 and Cg1 (Cg1 corresponds to the centroid of the aromatic ring). Within the packing, these one-dimensional strands are organized antiparallel, which is shown in Fig. 3. Different strands are connected via a weak (methyl)C–H···π(acetylene) contact involving C11–H11B and π2 (π2 is the midpoint of the CC bond). This interaction leads to a connection of different strands resulting in the formation of zigzag layers parallel to the ab plane (Fig. 3).

Related literature top

For general background to the Sonogashira–Hagihara coupling reaction and for applications of terminal arylalkynes, see: Chinchilla & Nájera (2007); Sonogashira (1998). For an alternative synthesis of the title compound, also including analytical data, see: Mayr & Halberstadt-Kausch (1982). For C–H···π hydrogen bonding, see: Nishio et al. (2009).

Experimental top

The title compound was prepared as follows: To a degassed mixture of 22.44 g (0.12 mol) 4-bromoanisole and 12.20 g (0.145 mol) 2-methylbut-3-yn-2-ol in 100 ml of diethylamine were added 0.27 g (1.2 mmol) palladium(II) acetate, 0.63 g (2.4 mmol) triphenylphosphane and 0.11 g (0.6 mmol) copper(I) iodide. The resulting mixture was refluxed for 15 h under argon, followed by a second addition of the catalyst mixture (same amounts as before) and another 15 h refluxing under argon. The solvent was removed in vacuo and the residue dissolved in water. The aqueous solution was extracted several times with diethyl ether, the combined organic phases dried over Na2SO4 and concentrated in vacuo. Column chromatographic purification [1. Al2O3, activity 1, eluent: diethyl ether; 2. silica gel, eluent: n-pentane/ethyl acetate (6:1 v/v)] and crystallization from cyclohexane yielded the title compound as colourless needles (16.8 g, 74% yield, m.p. 326 K). The analytical data are in agreement with the literature (Mayr & Halberstadt-Kausch, 1982), where the synthesis of the title compound is described using another procedure.

Refinement top

H atoms were positioned geometrically and allowed to ride on their respective parent atoms, with C—H = 0.98 Å and Uiso(H) = 1.5 Ueq(C) for methyl, C—H = 0.95 Å and Uiso(H) = 1.2 Ueq(C) for aryl and O—H = 0.84 Å and Uiso(H) = 1.5 Ueq(O) for hydroxy H atoms.

Structure description top

Terminal arylalkynes are of general interest in organic chemistry as they can be used for subsequent coupling reactions leading to diarylalkynes which are important building blocks in materials science (Chinchilla & Nájera, 2007). Compounds of this type can be prepared in a two-step reaction where an aryl halide is reacted with 2-methylbut-3-yn-2-ol (a monoprotected acetylene) in a Sonogashira-Hagihara reaction followed by deprotection of the resulting acetylenic compound using a base-catalysed retro-Favorsky elimination of acetone (Sonogashira, 1998).

Following this strategy, the title compound, which is important as an intermediate for the preparation of the terminal arylalkyne 4-ethinylanisole, was prepared via a Sonogashira-Hagihara coupling reaction starting from 4-bromoanisole and 2-methylbut-3-yn-2-ol. Crystallization from cyclohexane yielded colourless needles suitable for an X-ray crystal structure analysis on which is reported herein.

The title compound, C12H14O2, crystallizes in the orthorhombic space group Pbca. The asymmetric unit consists of one molecule which is illustrated in Fig. 1. The atoms C1–C6, C8–C10 and O1 are arranged nearly coplanar. Only the ether O atom O1 deviates slightly from the least-squares plane involving the mentioned atoms. The deviation between this least-squares plane and O1 is 0.0787 (8) Å, the deviation of all other atoms ranges from 0.0023 (11) to 0.0390 (10) Å. The methoxy methyl group is only marginally distorted towards this least-squares plane (torsion angles of -2.84 (18)° and 176.38 (11)° for C5–C4–O1–C7 and C3–C4–O1–C7, respectively). The angle between the least-squares plane (C1–C6, C8–C10, O1) and the least-squares plane of the atoms C9, C10 and O2 is 40.60 (11)°.

In the crystal, the hydroxy O atom O2 is involved in an O2–H1···O2 hydrogen bond leading to the formation of one-dimensional strands located parallel to the b axis (Fig. 2). Within these strands further stabilization is reached via a weak C–H···π interaction (Nishio et al., 2009) of the type (aryl)C–H···π(aryl) between C5–H5 and Cg1 (Cg1 corresponds to the centroid of the aromatic ring). Within the packing, these one-dimensional strands are organized antiparallel, which is shown in Fig. 3. Different strands are connected via a weak (methyl)C–H···π(acetylene) contact involving C11–H11B and π2 (π2 is the midpoint of the CC bond). This interaction leads to a connection of different strands resulting in the formation of zigzag layers parallel to the ab plane (Fig. 3).

For general background to the Sonogashira–Hagihara coupling reaction and for applications of terminal arylalkynes, see: Chinchilla & Nájera (2007); Sonogashira (1998). For an alternative synthesis of the title compound, also including analytical data, see: Mayr & Halberstadt-Kausch (1982). For C–H···π hydrogen bonding, see: Nishio et al. (2009).

Computing details top

Data collection: APEX2 (Bruker, 2007); cell refinement: SAINT (Bruker, 2007); data reduction: SAINT (Bruker, 2007); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008) and ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009).

Figures top
[Figure 1] Fig. 1. The molecular structure of the title compound, showing the atom numbering scheme. Displacement ellipsoids are drawn at the 50% probability level.
[Figure 2] Fig. 2. Molecular strands within the packing of the title compound. Hydrogen bonds are represented as dashed lines. H atoms not involved in any hydrogen bond have been omitted for clarity.
[Figure 3] Fig. 3. Packing diagram viewed down the b axis, showing the antiparallel orientation of the strands (symbolized by different background shading) as well as the resulting zigzag layers. The C11–H11B···Cg02 interactions between different strands are represented as dashed lines. H atoms not involved in hydrogen bonding between the strands have been omitted.
4-(4-Methoxyphenyl)-2-methylbut-3-yn-2-ol top
Crystal data top
C12H14O2Dx = 1.198 Mg m3
Mr = 190.23Melting point: 326 K
Orthorhombic, PbcaMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ac 2abCell parameters from 9596 reflections
a = 16.0390 (13) Åθ = 2.5–35.7°
b = 5.8399 (5) ŵ = 0.08 mm1
c = 22.5298 (19) ÅT = 153 K
V = 2110.3 (3) Å3Piece, colourless
Z = 80.60 × 0.28 × 0.24 mm
F(000) = 816
Data collection top
Bruker Kappa APEXII CCD
diffractometer
1956 independent reflections
Radiation source: fine-focus sealed tube1662 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.025
φ and ω scansθmax = 25.5°, θmin = 2.2°
Absorption correction: multi-scan
(SADABS; Bruker, 2007)
h = 1919
Tmin = 0.928, Tmax = 0.981k = 77
39990 measured reflectionsl = 2727
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.037Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.114H-atom parameters constrained
S = 1.10 w = 1/[σ2(Fo2) + (0.0611P)2 + 0.5536P]
where P = (Fo2 + 2Fc2)/3
1956 reflections(Δ/σ)max < 0.001
131 parametersΔρmax = 0.23 e Å3
0 restraintsΔρmin = 0.21 e Å3
Crystal data top
C12H14O2V = 2110.3 (3) Å3
Mr = 190.23Z = 8
Orthorhombic, PbcaMo Kα radiation
a = 16.0390 (13) ŵ = 0.08 mm1
b = 5.8399 (5) ÅT = 153 K
c = 22.5298 (19) Å0.60 × 0.28 × 0.24 mm
Data collection top
Bruker Kappa APEXII CCD
diffractometer
1956 independent reflections
Absorption correction: multi-scan
(SADABS; Bruker, 2007)
1662 reflections with I > 2σ(I)
Tmin = 0.928, Tmax = 0.981Rint = 0.025
39990 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0370 restraints
wR(F2) = 0.114H-atom parameters constrained
S = 1.10Δρmax = 0.23 e Å3
1956 reflectionsΔρmin = 0.21 e Å3
131 parameters
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.37704 (6)0.71897 (17)0.22519 (4)0.0376 (3)
O20.28653 (6)0.0689 (2)0.57437 (5)0.0557 (4)
H10.26690.20220.57340.084*
C10.37656 (7)0.4050 (2)0.39090 (5)0.0278 (3)
C20.42516 (8)0.3244 (2)0.34371 (5)0.0336 (3)
H20.45870.19180.34900.040*
C30.42501 (8)0.4349 (2)0.28967 (5)0.0343 (3)
H30.45870.37900.25820.041*
C40.37571 (7)0.6277 (2)0.28114 (5)0.0282 (3)
C50.32853 (8)0.7139 (2)0.32768 (5)0.0311 (3)
H50.29580.84800.32240.037*
C60.32961 (7)0.6019 (2)0.38213 (5)0.0310 (3)
H60.29750.66140.41400.037*
C70.32340 (10)0.9090 (3)0.21383 (6)0.0427 (4)
H7A0.26560.86540.22240.064*
H7B0.32830.95410.17210.064*
H7C0.33951.03780.23930.064*
C80.37456 (7)0.2863 (2)0.44679 (5)0.0310 (3)
C90.37190 (7)0.1876 (2)0.49347 (5)0.0317 (3)
C100.37033 (7)0.0710 (2)0.55174 (5)0.0313 (3)
C110.39535 (9)0.1775 (2)0.54539 (6)0.0374 (3)
H11A0.39140.25350.58410.056*
H11B0.45280.18670.53090.056*
H11C0.35800.25340.51710.056*
C120.42831 (10)0.1924 (2)0.59512 (6)0.0410 (3)
H12A0.41240.35400.59810.061*
H12B0.48590.18090.58090.061*
H12C0.42390.12020.63430.061*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0414 (5)0.0451 (6)0.0264 (5)0.0022 (4)0.0057 (4)0.0083 (4)
O20.0300 (5)0.0844 (9)0.0528 (6)0.0158 (5)0.0129 (4)0.0270 (6)
C10.0240 (6)0.0340 (6)0.0255 (6)0.0028 (4)0.0030 (4)0.0019 (5)
C20.0319 (6)0.0356 (7)0.0332 (7)0.0071 (5)0.0018 (5)0.0000 (5)
C30.0312 (6)0.0435 (7)0.0281 (6)0.0046 (5)0.0047 (5)0.0021 (5)
C40.0271 (6)0.0332 (6)0.0245 (6)0.0059 (5)0.0000 (4)0.0022 (5)
C50.0330 (6)0.0309 (6)0.0294 (6)0.0041 (5)0.0009 (5)0.0016 (5)
C60.0293 (6)0.0378 (7)0.0257 (6)0.0030 (5)0.0028 (4)0.0003 (5)
C70.0548 (9)0.0405 (8)0.0328 (7)0.0018 (6)0.0000 (6)0.0120 (6)
C80.0260 (6)0.0366 (7)0.0304 (6)0.0016 (5)0.0022 (4)0.0019 (5)
C90.0261 (6)0.0381 (7)0.0308 (7)0.0049 (5)0.0013 (4)0.0039 (5)
C100.0240 (6)0.0399 (7)0.0298 (6)0.0050 (5)0.0037 (4)0.0078 (5)
C110.0412 (7)0.0330 (7)0.0379 (7)0.0044 (5)0.0004 (5)0.0048 (5)
C120.0576 (9)0.0336 (7)0.0317 (7)0.0058 (6)0.0048 (6)0.0012 (5)
Geometric parameters (Å, º) top
O1—C41.3687 (14)C6—H60.9500
O1—C71.4271 (17)C7—H7A0.9800
O2—C101.4376 (14)C7—H7B0.9800
O2—H10.8400C7—H7C0.9800
C1—C61.3885 (18)C8—C91.2000 (18)
C1—C21.3998 (17)C9—C101.4791 (16)
C1—C81.4379 (17)C10—C111.5125 (18)
C2—C31.3778 (17)C10—C121.5239 (19)
C2—H20.9500C11—H11A0.9800
C3—C41.3895 (18)C11—H11B0.9800
C3—H30.9500C11—H11C0.9800
C4—C51.3875 (17)C12—H12A0.9800
C5—C61.3902 (17)C12—H12B0.9800
C5—H50.9500C12—H12C0.9800
C4—O1—C7117.28 (10)O1—C7—H7C109.5
C10—O2—H1109.5H7A—C7—H7C109.5
C6—C1—C2118.19 (11)H7B—C7—H7C109.5
C6—C1—C8120.78 (10)C9—C8—C1179.24 (12)
C2—C1—C8121.03 (11)C8—C9—C10178.32 (13)
C3—C2—C1120.84 (11)O2—C10—C9109.54 (10)
C3—C2—H2119.6O2—C10—C11105.87 (11)
C1—C2—H2119.6C9—C10—C11110.70 (10)
C2—C3—C4120.18 (11)O2—C10—C12110.31 (11)
C2—C3—H3119.9C9—C10—C12110.16 (10)
C4—C3—H3119.9C11—C10—C12110.18 (10)
O1—C4—C5124.29 (11)C10—C11—H11A109.5
O1—C4—C3115.72 (10)C10—C11—H11B109.5
C5—C4—C3119.99 (11)H11A—C11—H11B109.5
C4—C5—C6119.30 (11)C10—C11—H11C109.5
C4—C5—H5120.4H11A—C11—H11C109.5
C6—C5—H5120.4H11B—C11—H11C109.5
C1—C6—C5121.46 (11)C10—C12—H12A109.5
C1—C6—H6119.3C10—C12—H12B109.5
C5—C6—H6119.3H12A—C12—H12B109.5
O1—C7—H7A109.5C10—C12—H12C109.5
O1—C7—H7B109.5H12A—C12—H12C109.5
H7A—C7—H7B109.5H12B—C12—H12C109.5
C6—C1—C2—C31.33 (18)C2—C3—C4—C52.07 (18)
C8—C1—C2—C3178.08 (11)O1—C4—C5—C6177.57 (11)
C1—C2—C3—C40.57 (19)C3—C4—C5—C61.62 (18)
C7—O1—C4—C52.84 (18)C2—C1—C6—C51.78 (17)
C7—O1—C4—C3176.38 (11)C8—C1—C6—C5177.63 (11)
C2—C3—C4—O1177.19 (11)C4—C5—C6—C10.33 (18)
Hydrogen-bond geometry (Å, º) top
Cg1 and π2 are the centroid of the C1–C6 aromatic ring and midpoint of the C8C9 bond, respectively.
D—H···AD—HH···AD···AD—H···A
O2—H1···O2i0.842.313.1463 (7)178
C5—H5···Cg1i0.952.963.7452 (12)141
C11—H11B···π2ii0.982.803.7443 (14)161
Symmetry codes: (i) x+1/2, y+1/2, z; (ii) x+1, y, z+1.

Experimental details

Crystal data
Chemical formulaC12H14O2
Mr190.23
Crystal system, space groupOrthorhombic, Pbca
Temperature (K)153
a, b, c (Å)16.0390 (13), 5.8399 (5), 22.5298 (19)
V3)2110.3 (3)
Z8
Radiation typeMo Kα
µ (mm1)0.08
Crystal size (mm)0.60 × 0.28 × 0.24
Data collection
DiffractometerBruker Kappa APEXII CCD
Absorption correctionMulti-scan
(SADABS; Bruker, 2007)
Tmin, Tmax0.928, 0.981
No. of measured, independent and
observed [I > 2σ(I)] reflections
39990, 1956, 1662
Rint0.025
(sin θ/λ)max1)0.606
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.037, 0.114, 1.10
No. of reflections1956
No. of parameters131
H-atom treatmentH-atom parameters constrained
Δρmax, Δρmin (e Å3)0.23, 0.21

Computer programs: APEX2 (Bruker, 2007), SAINT (Bruker, 2007), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), SHELXTL (Sheldrick, 2008) and ORTEP-3 (Farrugia, 1997), SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009).

Hydrogen-bond geometry (Å, º) top
Cg1 and π2 are the centroid of the C1–C6 aromatic ring and midpoint of the C8C9 bond, respectively.
D—H···AD—HH···AD···AD—H···A
O2—H1···O2i0.842.313.1463 (7)178.0
C5—H5···Cg1i0.952.963.7452 (12)141.4
C11—H11B···π2ii0.982.803.7443 (14)160.8
Symmetry codes: (i) x+1/2, y+1/2, z; (ii) x+1, y, z+1.
 

Footnotes

Current address: Friedrich-Alexander-Universität Erlangen-Nürnberg, Emil-Fischer-Center, Lehrstuhl für Pharmazeutische Chemie, Schuhstr. 19, D-91052 Erlangen, Germany

References

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